{"id":"W2588414667","doi":"10.1074/jbc.m116.763854","title":"Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Receptor; Förster resonance energy transfer; Chemistry; Context (archaeology); Biophysics; HEK 293 cells; Biosensor; Functional selectivity; Arrestin; Ligand (biochemistry); Angiotensin II; Biochemistry; Biology; Fluorescence; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004576804,0.0001351513,0.0002381052,0.000009809342,0.000301917,0.00003837341,0.0003566015,0.000263732,0.00006309006],"category_scores_gemma":[0.0005227598,0.00008136177,0.0001751877,0.00002120419,0.0002314451,0.000008748872,0.0001923976,0.0002071017,4.210434e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001204116,"about_ca_system_score_gemma":0.00009927581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002270709,"about_ca_topic_score_gemma":2.489041e-7,"domain_scores_codex":[0.9990911,0.0000230377,0.0004165814,0.0001484455,0.000165434,0.0001553452],"domain_scores_gemma":[0.9985201,0.00001457619,0.0008670324,0.0002492473,0.000266066,0.00008292022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001344314,0.00003465859,0.0005607186,0.00002443385,0.00004203729,0.000001807181,0.0000172179,0.00001224841,0.998686,0.00004698399,0.0001204747,0.0003190149],"study_design_scores_gemma":[0.0005505456,0.0002603388,0.0002062727,0.00009454568,0.0000117743,0.00003008633,0.0000825079,0.00007422458,0.9957944,0.0001204441,0.002666973,0.0001078965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982831,0.0007168053,0.0003019779,0.0002758425,0.0001125555,0.0001207616,0.00001543062,0.000002489411,0.0001710118],"genre_scores_gemma":[0.9978805,0.00006460095,0.001500824,0.00006570694,0.0003065418,0.000002482862,0.00001556546,0.00000748162,0.0001563285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002891583,"threshold_uncertainty_score":0.3317837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02684825363162582,"score_gpt":0.2539833992760209,"score_spread":0.2271351456443951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}