{"id":"W2588439324","doi":"10.1093/annonc/mdw365.04","title":"Impact of palbociclib plus letrozole on health related quality of life (HRQOL) compared with letrozole alone in treatment naïve postmenopausal patients with ER+ HER2- metastatic breast cancer (MBC): results from PALOMA-2","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Letrozole; Palbociclib; Medicine; Quality of life (healthcare); Metastatic breast cancer; Breast cancer; Internal medicine; Placebo; Oncology; Cancer; Tamoxifen; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996005,0.0003979742,0.002240333,0.0002541698,0.00003430051,0.000002296621,0.0001494014,0.0001179305,0.000121301],"category_scores_gemma":[0.0001051828,0.0002235946,0.0001405694,0.0004066574,0.0004718078,0.0001316962,0.00003288327,0.0001736287,0.000004087932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001063631,"about_ca_system_score_gemma":0.001887613,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04493201,"about_ca_topic_score_gemma":0.006907988,"domain_scores_codex":[0.9963539,0.000536705,0.001503083,0.000521591,0.0005291158,0.0005556465],"domain_scores_gemma":[0.995865,0.0007154665,0.001932113,0.0006043789,0.0005772865,0.0003056791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3331877,0.01130324,0.5267341,0.0002190024,0.005157058,0.00007204284,0.004835468,0.001785429,0.007080564,0.0000612021,0.0003610119,0.1092031],"study_design_scores_gemma":[0.05816354,0.03908925,0.8992811,0.0008459219,0.0001035424,0.00001100719,0.0002744453,0.00001153686,0.001820722,0.00008273742,0.0001080101,0.0002082201],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872426,0.0008233995,0.00002903876,0.005851753,0.00005190813,0.0009852311,0.004865133,0.00002580132,0.0001251742],"genre_scores_gemma":[0.9981601,0.0002698722,0.0006926167,0.0004306122,0.00003159263,0.0000603657,0.0002640469,0.00005052551,0.0000403304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3725469,"threshold_uncertainty_score":0.9614279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08483000578050044,"score_gpt":0.411805459225645,"score_spread":0.3269754534451446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}