{"id":"W2588456788","doi":"10.1016/j.cotox.2017.01.013","title":"AHR toxicity and signaling: Role of TIPARP and ADP-ribosylation","year":2017,"lang":"en","type":"article","venue":"Current Opinion in Toxicology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Universitetet i Oslo","keywords":"Aryl hydrocarbon receptor; Poly ADP ribose polymerase; Toxicity; Transcription factor; ADP-ribosylation; Cell biology; Signal transduction; Chemistry; Aryl hydrocarbon receptor nuclear translocator; Receptor; Biology; Gene; Biochemistry; Polymerase; Enzyme; NAD+ kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299997,0.0001027838,0.0002754638,0.0001183936,0.00008862693,0.00001424845,0.00006869293,0.0001155812,0.00008009195],"category_scores_gemma":[0.000132545,0.0001014156,0.00002705695,0.00004133397,0.0002692326,0.00009948475,0.00006377266,0.0001690694,0.000003054638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000046399,"about_ca_system_score_gemma":0.00005698891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001077232,"about_ca_topic_score_gemma":0.00000522553,"domain_scores_codex":[0.9991713,0.00005533977,0.0002765664,0.0002343079,0.0001082668,0.0001542111],"domain_scores_gemma":[0.9993226,0.00007657131,0.0002197699,0.0002435853,0.0000556422,0.00008185587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007238563,0.0007384495,0.6748761,0.0006757365,0.00004611594,0.000001711754,0.001394404,0.00001510599,0.2021473,0.009400444,0.001235472,0.1087452],"study_design_scores_gemma":[0.009790043,0.001177285,0.8377739,0.0009965681,0.00003329458,0.00006838447,0.0002157732,0.001815651,0.09065606,0.01086082,0.04628902,0.0003231745],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918522,0.004724474,0.0001350514,0.00103614,0.001267508,0.0003207859,0.00001557714,0.00001655041,0.0006316997],"genre_scores_gemma":[0.9979249,0.00152418,0.0001722684,0.00004113877,0.0002635635,0.00003177926,0.00001584634,0.000008861511,0.00001740971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1628978,"threshold_uncertainty_score":0.4135608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08100227169796398,"score_gpt":0.4026833174039008,"score_spread":0.3216810457059368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}