{"id":"W2588506855","doi":"10.1093/annonc/mdw333.04","title":"Effects of nanoliposomal irinotecan (nal-IRI; MM-398) ± 5-fluorouracil and leucavorin (5-FU/LV) on quality of life (QoL) in patients (pts) with metastatic pancreatic adenocarcinoma (mPAC) previously treated with gemcitabine-based therapy: results from the phase 3 NAPOLI-1 study","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Quality of life (healthcare); Gemcitabine; Internal medicine; Clinical endpoint; Performance status; Surgery; Physical therapy; Gastroenterology; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005405255,0.000406091,0.000608905,0.0001679156,0.0001627853,0.000294083,0.0002631916,0.0003599256,0.0009410335],"category_scores_gemma":[0.000558559,0.0001596168,0.0009554856,0.0001980935,0.0003444716,0.0003613228,0.0001818592,0.0009740977,0.0001254847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004707813,"about_ca_system_score_gemma":0.0003488894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113372,"about_ca_topic_score_gemma":0.00287752,"domain_scores_codex":[0.9998248,0.0000933226,0.00001219343,0.0000232347,0.00001531361,0.00003120766],"domain_scores_gemma":[0.9996895,0.0001002387,0.00007907989,0.0000159684,0.000012223,0.0001028957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7611703,0.03326777,0.02866903,0.0007259026,0.003471324,0.0001962165,0.000298693,0.002109227,0.04779216,0.0001036405,0.001041737,0.121154],"study_design_scores_gemma":[0.1480536,0.657393,0.179436,0.0000699739,0.002829317,0.000270497,0.000264713,0.001663997,0.008193955,0.000130882,0.0016443,0.00004976053],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987916,0.0007678732,0.00002890277,0.00005158045,0.00001186613,0.00004118168,0.00008672488,0.000004850554,0.0002153509],"genre_scores_gemma":[0.9987051,0.000593311,0.00009680408,0.0001017686,0.00002189704,0.00004886606,0.000201204,0.000002530692,0.0002284929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113372,"threshold_uncertainty_score":0.003415823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09235539799579844,"score_gpt":0.3864167956391834,"score_spread":0.2940613976433849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}