{"id":"W2588538983","doi":"10.1182/blood.v114.22.680.680","title":"A Randomized, Double-Blind, Placebo-Controlled Phase 1/2 Study to Determine the Safety and Efficacy of Romiplostim in Children with Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP).","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Romiplostim; Adverse effect; Thrombocytopenic purpura; Placebo; Randomized controlled trial; Internal medicine; Incidence (geometry); Clinical endpoint; Platelet; Pediatrics; Thrombopoietin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00225794,0.001484042,0.003840693,0.0004861951,0.0005817932,0.0008500435,0.001117447,0.002354976,0.006751996],"category_scores_gemma":[0.002063198,0.0009350646,0.001368539,0.0004394253,0.001439767,0.001145185,0.0003657082,0.002984595,0.001029938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006893648,"about_ca_system_score_gemma":0.001894922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006939893,"about_ca_topic_score_gemma":0.001473827,"domain_scores_codex":[0.9991391,0.0004738411,0.00006271244,0.0001407035,0.00006431207,0.0001192376],"domain_scores_gemma":[0.9982816,0.0005191042,0.0004219488,0.000133647,0.0001200118,0.0005237686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9693695,0.01448044,0.0008064884,0.0004892064,0.0003786399,0.00006283922,0.00004178448,0.0001506069,0.003356311,0.00008072764,0.0005592844,0.01022407],"study_design_scores_gemma":[0.929237,0.0688995,0.001063285,0.00001499512,0.0001115347,0.00002669511,0.000008507956,0.0001204041,0.0002052026,0.00003230789,0.0002749042,0.000005726328],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805127,0.003744008,0.0008697093,0.0005728184,0.0005438434,0.01016012,0.001504815,0.0001545844,0.001937263],"genre_scores_gemma":[0.9694185,0.002847436,0.003618655,0.001853046,0.0007331675,0.01761214,0.001364699,0.0000353167,0.002517114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006751996,"threshold_uncertainty_score":0.02258766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508882418904442,"score_gpt":0.2849444824179769,"score_spread":0.2698556582289325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}