{"id":"W2588550827","doi":"10.1016/j.jpba.2017.01.058","title":"Assessment of the structure of pegylated-recombinant protein therapeutics by the NMR fingerprint assay","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; Health Canada","funders":"Genentech; Amgen","keywords":"Chemistry; PEGylation; PEG ratio; Polyethylene glycol; Filgrastim; Recombinant DNA; Pegylated interferon; Pharmacology; Biochemistry; Toxicity; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003928744,0.0003698138,0.0001847925,0.0002841338,0.0001948618,0.0002148685,0.0001883075,0.0003436907,0.0009235686],"category_scores_gemma":[0.0006524925,0.0001364028,0.0002192555,0.0002411656,0.0002279792,0.0003806137,0.0001629038,0.0005423439,0.0003196506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615222,"about_ca_system_score_gemma":0.0002343828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005830939,"about_ca_topic_score_gemma":0.0005656069,"domain_scores_codex":[0.999835,0.00003438985,0.00001359179,0.00003170723,0.00005553478,0.00002975609],"domain_scores_gemma":[0.9996923,0.00006573783,0.00009330649,0.00002373082,0.00008354796,0.00004138646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007091848,0.00001347677,0.0001257994,0.00001196287,0.000003620077,0.00001087629,0.00001219125,0.00006476535,0.9986957,0.0000363492,0.0000111449,0.0009432025],"study_design_scores_gemma":[0.000003622676,0.000141929,0.001492502,0.000002692879,0.00001250047,0.00006439247,0.00001253484,0.001215071,0.9965261,0.00002872259,0.0004957806,0.000004170856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714822,0.0008155558,0.02483515,0.0001349068,0.00002581389,0.00006881445,0.0004885214,0.0001187672,0.00203026],"genre_scores_gemma":[0.9739082,0.0007416485,0.0212537,0.0001058537,0.00001491882,0.00008417723,0.0007846873,0.00003982706,0.003066972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009235686,"threshold_uncertainty_score":0.003089666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175263698123888,"score_gpt":0.3447608040138103,"score_spread":0.3272344342014215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}