{"id":"W2588614488","doi":"10.1093/neuonc/now212.159","title":"CBIO-21. STAT3 REGULATES AN SL/PL TRANSITION IN BTICs THROUGH AN EMT-LIKE PROCESS MEDIATED BY SLUG","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Calgary","funders":"","keywords":"Slug; Epithelial–mesenchymal transition; Biology; STAT3; Transcription factor; Cancer research; Transcriptome; Twist transcription factor; Cell biology; Signal transduction; Downregulation and upregulation; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708229,0.0003625868,0.0003667899,0.0005299028,0.0004274466,0.000569078,0.0003981438,0.0004557927,0.009720238],"category_scores_gemma":[0.000117964,0.0002181362,0.0006809959,0.0004709779,0.0004352215,0.0002649432,0.0002532054,0.002008753,0.002850324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007842496,"about_ca_system_score_gemma":0.0007878469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005066462,"about_ca_topic_score_gemma":0.007464235,"domain_scores_codex":[0.9995853,0.00004307772,0.00003914969,0.00007939604,0.00009582838,0.0001572028],"domain_scores_gemma":[0.9998432,0.00002084304,0.00003128952,0.00001648914,0.00001820136,0.00006983145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007969773,0.0002800856,0.0003561423,0.0001520407,0.00001973684,0.00008172313,0.00004212423,0.0001833351,0.9940504,0.0003726324,0.001171812,0.002492812],"study_design_scores_gemma":[0.000194551,0.000689753,0.01497728,0.00002989836,0.0000530916,0.0003922826,0.0001324021,0.002475825,0.9609625,0.0002198945,0.01985338,0.00001922304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548185,0.005456577,0.004540704,0.001539727,0.0004850299,0.0001606267,0.01636006,0.001186588,0.01545224],"genre_scores_gemma":[0.957675,0.001603543,0.003314078,0.0006848402,0.00003837491,0.0003242622,0.01332008,0.0002189699,0.02282085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009720238,"threshold_uncertainty_score":0.03251743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155257067953133,"score_gpt":0.3134371555235025,"score_spread":0.2979114487281893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}