{"id":"W2588614813","doi":"10.1016/s2213-8587(17)30044-x","title":"Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study","year":2017,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Amgen","keywords":"Medicine; Evolocumab; Interim analysis; Ezetimibe; Internal medicine; Adverse effect; PCSK9; LDL apheresis; Familial hypercholesterolemia; Cholesterol; Clinical trial; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003997841,0.001450062,0.003747944,0.0003290125,0.0004808011,0.001999114,0.0008960458,0.00133381,0.001180487],"category_scores_gemma":[0.002759829,0.0007361562,0.005043406,0.0004816596,0.0009108104,0.001591165,0.0005972221,0.002947987,0.0004445287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007340344,"about_ca_system_score_gemma":0.0006300984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005702891,"about_ca_topic_score_gemma":0.001275558,"domain_scores_codex":[0.9980175,0.0009570752,0.0001236463,0.000341677,0.0002369347,0.0003231424],"domain_scores_gemma":[0.9973621,0.0008468622,0.0006170156,0.0006757379,0.0001583718,0.0003398731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8902584,0.001842491,0.06902315,0.0003383918,0.01135038,0.0003490044,0.0001799013,0.001143355,0.004916023,0.0001465866,0.00105168,0.01940054],"study_design_scores_gemma":[0.2157091,0.1347942,0.5919554,0.0002595795,0.04144921,0.001097206,0.0006474893,0.004247811,0.004191088,0.001220479,0.004122331,0.0003060438],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970661,0.001651003,0.0002265904,0.00009144723,0.00008449199,0.0000521316,0.0004502642,0.00001581736,0.0003621473],"genre_scores_gemma":[0.9966028,0.0004138891,0.0002784357,0.0002420079,0.0001286558,0.00009224577,0.00176724,0.00001246079,0.0004622961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003997841,"threshold_uncertainty_score":0.0211429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05832711720972705,"score_gpt":0.344721704709172,"score_spread":0.2863945874994449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}