{"id":"W2588634924","doi":"10.1093/neuonc/now212.288","title":"EXTH-44. NONE MGMT AND MMR DEPENDENT RADIOSENSITIZATION TO TREAT MALIGNANT GLIOMAS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Montreal Neurological Institute and Hospital","funders":"","keywords":"Temozolomide; Cancer research; DNA repair; Methyltransferase; Medicine; Radiation therapy; Chemotherapy; Oncology; DNA damage; Internal medicine; Biology; Glioma; Methylation; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011158,0.0003698007,0.0003263048,0.000458668,0.0001583243,0.0002103585,0.0002682679,0.0003208025,0.00645007],"category_scores_gemma":[0.00005069173,0.0001177715,0.0002396165,0.0002490537,0.0001365462,0.000143251,0.0002706138,0.0009014943,0.00208244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211423,"about_ca_system_score_gemma":0.0003060405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006034951,"about_ca_topic_score_gemma":0.001406134,"domain_scores_codex":[0.9999287,0.000007792453,0.000003492967,0.00001088443,0.00002618534,0.00002290389],"domain_scores_gemma":[0.9999794,9.900676e-7,0.000004009193,0.00000248679,0.000003407744,0.000009583083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001535846,0.001573309,0.0007244413,0.001231051,0.0001197795,0.0005330314,0.00009468029,0.000779104,0.7263075,0.002379296,0.007700323,0.2570216],"study_design_scores_gemma":[0.00130271,0.01136195,0.02074553,0.0002071314,0.0002314046,0.003535992,0.00007654799,0.001284765,0.6320474,0.001000105,0.3281548,0.00005171101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8263894,0.09538797,0.006720304,0.002214063,0.001324427,0.000850571,0.00329065,0.001775688,0.06204692],"genre_scores_gemma":[0.8974156,0.0359475,0.00384438,0.001011288,0.0002065519,0.0003842963,0.00399174,0.00012519,0.05707353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00645007,"threshold_uncertainty_score":0.0215776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811856725643998,"score_gpt":0.2825633519288493,"score_spread":0.2644447846724093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}