{"id":"W2588683809","doi":"10.1371/journal.pntd.0005390","title":"Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response","year":2017,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Vetenskapsrådet; National Institutes of Health; Hjärt-Lungfonden","keywords":"Biology; Immunology; Antigen; Immune system; Mycobacterium tuberculosis; Microbiology; Tuberculosis; Schistosoma mansoni; Acquired immune system; Helminths; Schistosomiasis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002222417,0.0001737137,0.000154243,0.00008822305,0.0001131494,0.0001403686,0.000089503,0.0002231426,0.001792009],"category_scores_gemma":[0.0001667558,0.00007905801,0.0001348199,0.00006255908,0.0001267356,0.0001115223,0.0001798348,0.0002217341,0.0003008219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005776176,"about_ca_system_score_gemma":0.00009397082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245241,"about_ca_topic_score_gemma":0.000187612,"domain_scores_codex":[0.999905,0.00003092489,0.000008861212,0.0000140076,0.00001383097,0.00002741359],"domain_scores_gemma":[0.9998888,0.00004587079,0.00001477006,0.00001072529,0.00001979548,0.00002005053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000853434,0.0001274298,0.00166918,0.0001373209,0.000007687663,0.0001071072,0.00005319082,0.00003564553,0.9947614,0.0000231054,0.00003737705,0.002187019],"study_design_scores_gemma":[0.0001399871,0.007192868,0.06519648,0.00004502551,0.00007332622,0.001123992,0.0002244227,0.0004369059,0.9222615,0.0001292525,0.003166311,0.000009932411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977372,0.001371423,0.0001319969,0.0000449006,0.00001749126,0.00001975315,0.0001051441,0.000005085462,0.0005669785],"genre_scores_gemma":[0.9979743,0.000718576,0.0003446541,0.00006581672,0.00002267381,0.0000282318,0.0001861803,0.000002696903,0.0006568034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792009,"threshold_uncertainty_score":0.005994856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185402885658523,"score_gpt":0.2946860170387287,"score_spread":0.2761457284728764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}