{"id":"W2588711318","doi":"10.1093/neuonc/now212.178","title":"CSIG-17. COMPENSATORY ACTIVATION OF STAT3 TRIGGERED BY EGFR INHIBITION: A MECHANISM OF RESISTANCE IN GBM BRAIN TUMOR INITIATING CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Calgary","funders":"","keywords":"Afatinib; Cancer research; STAT3; EGFR inhibitors; Signal transduction; In vivo; Biology; Erlotinib; Epidermal growth factor receptor; Cancer; Medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003205434,0.000130691,0.0004823095,0.0002220611,0.00003414937,0.000002941077,0.00005997579,0.000102304,0.0003342502],"category_scores_gemma":[0.0005992266,0.0001088687,0.00008222439,0.0002292608,0.00009708435,0.0001174831,0.0000326894,0.0002286668,0.000007283677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203448,"about_ca_system_score_gemma":0.0003030262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003936605,"about_ca_topic_score_gemma":0.00006499009,"domain_scores_codex":[0.9984376,0.0002340319,0.0006766883,0.0002589246,0.0001936161,0.000199125],"domain_scores_gemma":[0.9977179,0.001333072,0.0004956645,0.0002030264,0.0001807433,0.00006955861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000591406,0.0003325038,0.00007898782,0.00007062747,0.00001522735,0.00004712616,0.0005052066,0.000001737888,0.9860748,0.001470602,0.01002204,0.0007897071],"study_design_scores_gemma":[0.003492218,0.00115062,0.0002262616,0.0004020181,0.00002342108,0.00002439086,0.0003074072,0.00003472101,0.9697326,0.0004727737,0.02404291,0.00009066287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880258,0.00003538737,0.00170106,0.004248606,0.0002481884,0.0004484125,0.0001110128,0.00003564474,0.005145843],"genre_scores_gemma":[0.997322,0.00001577892,0.000681682,0.001726211,0.00007545297,0.00003024231,0.00001814003,0.00002249543,0.000108061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01634222,"threshold_uncertainty_score":0.4439537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630862211128952,"score_gpt":0.2927558111017244,"score_spread":0.2664471889904349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}