{"id":"W2588711318","doi":"10.1093/neuonc/now212.178","title":"CSIG-17. COMPENSATORY ACTIVATION OF STAT3 TRIGGERED BY EGFR INHIBITION: A MECHANISM OF RESISTANCE IN GBM BRAIN TUMOR INITIATING CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Calgary","funders":"","keywords":"Afatinib; Cancer research; STAT3; EGFR inhibitors; Signal transduction; In vivo; Biology; Erlotinib; Epidermal growth factor receptor; Cancer; Medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719889,0.0003691056,0.0006455339,0.0003295414,0.0001485338,0.0004135183,0.0003098749,0.0003722477,0.002033979],"category_scores_gemma":[0.0001252953,0.0001452256,0.000436542,0.0004932647,0.0002128508,0.0001524539,0.0001648,0.0009427916,0.0008168957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004228076,"about_ca_system_score_gemma":0.0005639634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421525,"about_ca_topic_score_gemma":0.002021063,"domain_scores_codex":[0.9998251,0.00001979122,0.00001692797,0.00002224168,0.00005365515,0.00006242107],"domain_scores_gemma":[0.9999298,0.00001115706,0.00001257371,0.00001282126,0.00001067009,0.00002302948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009069072,0.0003923552,0.001408239,0.0001972731,0.00003864643,0.0003824293,0.00006019375,0.0007520185,0.9812855,0.0004221017,0.0009181595,0.01323625],"study_design_scores_gemma":[0.0001852589,0.002839704,0.01302749,0.00001617856,0.00005636982,0.001178827,0.00007765211,0.002264173,0.970349,0.0002225312,0.009769578,0.00001312703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890914,0.002599372,0.001089334,0.000326161,0.00009023178,0.0001099708,0.00219024,0.0002169702,0.004286394],"genre_scores_gemma":[0.9907958,0.001379771,0.001271845,0.0001860712,0.00001337285,0.00009718756,0.00356738,0.00002663569,0.002662032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002033979,"threshold_uncertainty_score":0.006804347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630862211128952,"score_gpt":0.2927558111017244,"score_spread":0.2664471889904349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}