{"id":"W2588714680","doi":"10.1093/annonc/mdw368.15","title":"A phase Ib study of lumretuzumab, a glycoengineered monoclonal antibody targeting HER3, in combination with carboplatin and paclitaxel as 1st-line treatment in patients with squamous non-small cell lung cancer","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Paclitaxel; Monoclonal antibody; Oncology; Cancer research; Lung cancer; Cancer; Internal medicine; Antibody; Chemotherapy; Immunology; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001475575,0.001424948,0.002406241,0.000638178,0.0005938369,0.001325649,0.001098906,0.00153847,0.002966034],"category_scores_gemma":[0.0007932479,0.0007871542,0.001905085,0.0005282072,0.001154419,0.001166961,0.000345757,0.003500202,0.000928051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001164567,"about_ca_system_score_gemma":0.001631526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001729481,"about_ca_topic_score_gemma":0.005285945,"domain_scores_codex":[0.9995586,0.0002069662,0.00001983995,0.00006930754,0.00002750632,0.0001176229],"domain_scores_gemma":[0.9994918,0.00008242531,0.00006248149,0.00003985155,0.00002790749,0.0002956114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7085535,0.1031881,0.007626684,0.001009328,0.001941023,0.0005124116,0.0005600716,0.004513266,0.04446977,0.0005084812,0.00477791,0.1223395],"study_design_scores_gemma":[0.4553154,0.5239375,0.01016244,0.0000452389,0.0007716437,0.0004356543,0.0001430972,0.001520155,0.004326247,0.0002383253,0.003058326,0.00004585238],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901751,0.00309823,0.0005955918,0.0006210277,0.0002393785,0.001839096,0.0008316861,0.000137684,0.00246221],"genre_scores_gemma":[0.9888791,0.003097647,0.001206074,0.000799078,0.000180864,0.001290552,0.002001693,0.00004653579,0.002498486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002966034,"threshold_uncertainty_score":0.009922385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133282435025224,"score_gpt":0.3781762109981817,"score_spread":0.3468433866479295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}