{"id":"W2588762403","doi":"10.1182/blood.v116.21.290.290","title":"The Anti-Malarial Mefloquine Demonstrates Preclinical Activity In Leukemia and Myeloma, and Is Dependent Upon Toll-Like Receptor Signaling for Its Cytotoxicity","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Mefloquine; Leukemia; Pharmacology; Medicine; Cytotoxic T cell; Bone marrow; Immunology; Biology; Malaria; In vitro; Chloroquine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953403,0.0003559805,0.0003136416,0.000291514,0.0001383537,0.0002207473,0.0002235632,0.0001754879,0.00320769],"category_scores_gemma":[0.0001663962,0.0001176051,0.0002161146,0.0001859404,0.000165432,0.0001819833,0.0001211233,0.0005063236,0.0004723022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049467,"about_ca_system_score_gemma":0.0002106749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009072998,"about_ca_topic_score_gemma":0.002360479,"domain_scores_codex":[0.999889,0.00001852276,0.000008865314,0.00001598911,0.00004256154,0.00002507752],"domain_scores_gemma":[0.999903,0.00002202986,0.00001820625,0.000009898018,0.00003122861,0.00001563655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001843028,0.0001208161,0.0002638926,0.0001339711,0.000008660439,0.00005490678,0.00001074625,0.0002095601,0.9930575,0.00008133826,0.0002394418,0.005634842],"study_design_scores_gemma":[0.00005791784,0.003763949,0.005041085,0.00002531537,0.00002922261,0.0003592351,0.00001847011,0.0007438774,0.9829532,0.0000641122,0.006936038,0.000007667662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686719,0.009290314,0.008369754,0.0003125205,0.00005163092,0.0003569897,0.003641742,0.0002669423,0.009038214],"genre_scores_gemma":[0.9820125,0.005135976,0.003873979,0.0001260158,0.00001388129,0.00008501315,0.003042858,0.00003602115,0.005673736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00320769,"threshold_uncertainty_score":0.01073074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239784894916359,"score_gpt":0.2654720961250271,"score_spread":0.2530742471758636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}