{"id":"W2588763838","doi":"10.1182/blood.v110.11.3175.3175","title":"A Distal Single Nucleotide Polymorphism Disrupts Development-Dependent Long-Range Transcriptional Regulation of the PU.1 Gene through the Chromatin-Remodeling Protein SATB1 in Acute Myeloid Leukemia.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Molecular biology; Chromatin; Biology; Chromatin remodeling; Transcription factor; Myeloid; Promoter; Enhancer; Chromatin immunoprecipitation; Chemistry; Cancer research; Gene expression; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550178,0.0003674438,0.0001843951,0.0002801346,0.0001352643,0.000179,0.000278859,0.0003273511,0.00205395],"category_scores_gemma":[0.0001102941,0.0002745633,0.0003153572,0.0001265495,0.0002682267,0.00006595031,0.0001982373,0.0007680686,0.0005037044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230825,"about_ca_system_score_gemma":0.0001460428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003806124,"about_ca_topic_score_gemma":0.001018319,"domain_scores_codex":[0.9998343,0.00004485835,0.00002085393,0.00003595392,0.00004005208,0.00002396549],"domain_scores_gemma":[0.9998493,0.00003399059,0.00005417506,0.00001108883,0.000004491713,0.00004686217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009130693,0.00004085114,0.0001792669,0.00001280125,0.000006032139,0.00007279865,0.000004853227,0.00004348598,0.9989257,0.00007160709,0.00002341146,0.0005276636],"study_design_scores_gemma":[0.0001083344,0.0009329038,0.02421746,0.00001740124,0.00005822456,0.00115714,0.00002094288,0.004373777,0.9663649,0.0001084235,0.002627233,0.00001338095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950922,0.0005772372,0.003045285,0.0001129443,0.00005931367,0.00004726878,0.0004706055,0.0001038526,0.000491399],"genre_scores_gemma":[0.9963831,0.0001979446,0.001435266,0.00007143784,0.00001068559,0.00003308591,0.0004246618,0.00003326115,0.001410513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205395,"threshold_uncertainty_score":0.006871164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072190971868944,"score_gpt":0.2216207226695497,"score_spread":0.2108988129508602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}