{"id":"W2588786370","doi":"10.1182/blood.v128.22.327.327","title":"Inhibitor Development in Previously Untreated Patients with Severe Hemophilia a Treated with Nuwiq®, a New Generation Recombinant FVIII of Human Origin","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Institute for Clinical Evaluative Sciences; BC Children's Hospital; SickKids Foundation; Hospital for Sick Children; Translational Research in Oncology","funders":"","keywords":"Immunogenicity; Von Willebrand factor; Medicine; Recombinant DNA; Titer; Incidence (geometry); Cumulative incidence; Immunology; Internal medicine; Antibody; Gastroenterology; Cohort; Biology; Platelet; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004169454,0.0001821787,0.0005500758,0.0002575019,0.0002178813,0.0003578727,0.0001431596,0.0002209292,0.0007206794],"category_scores_gemma":[0.0006977365,0.0001351783,0.0004351184,0.0003350338,0.0002274442,0.0002672078,0.0001897355,0.000390069,0.0001079707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004091955,"about_ca_system_score_gemma":0.0002982242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007804069,"about_ca_topic_score_gemma":0.001044226,"domain_scores_codex":[0.9996877,0.0001060485,0.00002745433,0.00006606415,0.00007399653,0.00003884849],"domain_scores_gemma":[0.999471,0.000129515,0.0002270904,0.00001836912,0.0000204695,0.0001335007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009318055,0.0009469758,0.9449164,0.0002556403,0.0007333402,0.001653799,0.0001945173,0.0003222561,0.004733121,0.00008661253,0.0009839297,0.03585531],"study_design_scores_gemma":[0.001452228,0.01944412,0.9695929,0.00006213251,0.0004361393,0.005171568,0.0001281145,0.0005190428,0.001285304,0.00006400115,0.0018269,0.00001743551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967583,0.002583354,0.00004766447,0.00002201413,0.000005533308,0.00002725666,0.0001089359,0.000003944071,0.0004430019],"genre_scores_gemma":[0.9988092,0.0006875298,0.00005486379,0.00007339416,0.0000173749,0.00002283863,0.0002222751,8.859047e-7,0.000111616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007804069,"threshold_uncertainty_score":0.002968967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02320265702288769,"score_gpt":0.2598090096925003,"score_spread":0.2366063526696126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}