{"id":"W2588796936","doi":"10.1093/neuonc/now212.613","title":"PDCT-09. HYPERMUTATION AND NEOANTIGEN FORMATION IS DIAGNOSTIC AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION IN CHILDHOOD BIALLELIC MISMATCH REPAIR DEFICIENT BRAIN TUMORS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University Health Centre; Hôpital de l'Enfant-Jésus; Mount Sinai Hospital; CancerCare Manitoba; Montreal Children's Hospital; Izaak Walton Killam Health Centre; Université Laval; Hospital for Sick Children","funders":"","keywords":"Somatic hypermutation; DNA mismatch repair; Immune system; Medicine; Cancer research; Immunology; DNA repair; Biology; Genetics; Antibody; Gene; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183499,0.000162841,0.0002006488,0.0004774662,0.0001705111,0.000366598,0.0002050712,0.0002492953,0.001105363],"category_scores_gemma":[0.0006558479,0.00008436136,0.00008870431,0.0003191324,0.0001946531,0.0001245582,0.0002269629,0.0002323658,0.0002447685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002618196,"about_ca_system_score_gemma":0.0001422249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042753,"about_ca_topic_score_gemma":0.001381046,"domain_scores_codex":[0.9998586,0.00002487551,0.00001848201,0.00004291979,0.00003446532,0.00002067946],"domain_scores_gemma":[0.9995723,0.0001033766,0.0001552757,0.0000168066,0.00004049748,0.000111648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009869669,0.00005202699,0.9727787,0.00001892885,0.0000225565,0.0009981125,0.00003124912,0.0002137454,0.01506719,0.00003458784,0.0003248188,0.009471214],"study_design_scores_gemma":[0.00002535089,0.0004803214,0.9803695,0.000007494737,0.00003190454,0.008439034,0.00006261189,0.001274301,0.008081957,0.00004397682,0.001178112,0.000005308147],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983468,0.0002395544,0.0002367168,0.0000279969,0.000004035599,0.000009647967,0.0003817347,0.00001684941,0.0007365205],"genre_scores_gemma":[0.9985721,0.00009545993,0.0003944121,0.00002064734,0.000003698836,0.000008122913,0.0006844645,0.000005246387,0.0002158601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105363,"threshold_uncertainty_score":0.003697813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136306417892614,"score_gpt":0.2617202123091235,"score_spread":0.2503571481301974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}