{"id":"W2588865017","doi":"10.1161/circgenetics.116.001598","title":"Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure","year":2017,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba","funders":"University of Manitoba","keywords":"Mesenchymal stem cell; Heart failure; Internal medicine; Cardiac fibrosis; Endocrinology; Biology; Fibrosis; Medicine; Cancer research; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005597685,0.0002988547,0.0003572423,0.00008897205,0.0007630261,0.0003108359,0.0003560715,0.0002769813,0.00001816859],"category_scores_gemma":[0.0002242428,0.0003138724,0.0004723053,0.00007996437,0.0003707797,0.00001919946,0.000331884,0.0001817115,0.0000203767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003191261,"about_ca_system_score_gemma":0.0002127389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002154435,"about_ca_topic_score_gemma":0.0001141821,"domain_scores_codex":[0.9977109,0.0002064203,0.0002689373,0.0007508873,0.0005505303,0.000512275],"domain_scores_gemma":[0.9976787,0.00001743811,0.00008418839,0.001674378,0.0002580647,0.0002872448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004502758,0.00007785677,0.1276676,0.00009738383,0.0004804475,0.00002864249,0.00004123712,0.002179189,0.8657979,0.00004620208,0.0009287946,0.002609745],"study_design_scores_gemma":[0.002149151,0.0002939259,0.5358531,0.00002385764,0.0002936074,0.0002705308,0.0000739741,0.0009908405,0.3659821,0.0000641419,0.09319486,0.0008098622],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845869,0.01214129,0.002086191,0.000101799,0.0001670925,0.0005882052,0.00006366708,0.00002348017,0.0002413998],"genre_scores_gemma":[0.9976618,0.0003682274,0.001273958,0.00009083754,0.0003514009,0.00005130022,0.0001047236,0.00005112587,0.00004660262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4998157,"threshold_uncertainty_score":0.9999313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512022078174154,"score_gpt":0.2530394994786297,"score_spread":0.2379192786968882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}