{"id":"W2588907697","doi":"10.1093/annonc/mdw374.03","title":"Clinical activity of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in patients (pts) with high-grade ovarian carcinoma (HGOC) and a BRCA mutation (BRCAmut): Analysis of pooled data from Study 10 (parts 1, 2a, and 3) and ARIEL2 (parts 1 and 2)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Discontinuation; Nausea; Adverse effect; BRCA mutation; Anemia; PARP inhibitor; Gastroenterology; Surgery; Oncology; Cancer; Ovarian cancer; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003076051,0.0005458159,0.001704985,0.000566937,0.0001789723,0.0008314612,0.0005106472,0.0008009883,0.0009228284],"category_scores_gemma":[0.003771844,0.0004286199,0.002130741,0.001023533,0.0004339213,0.0006985052,0.0003765767,0.001200343,0.0001881737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004698614,"about_ca_system_score_gemma":0.0004569416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007147405,"about_ca_topic_score_gemma":0.001827793,"domain_scores_codex":[0.9982234,0.001047542,0.0001627335,0.0002705313,0.000188694,0.0001069884],"domain_scores_gemma":[0.9971289,0.001308497,0.0009325216,0.0002252091,0.000115397,0.0002894468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.3176124,0.001346873,0.5923826,0.0008506589,0.03013335,0.0002773684,0.0001605579,0.002174213,0.006202694,0.00009932183,0.001140523,0.04761945],"study_design_scores_gemma":[0.01971931,0.04340143,0.9150487,0.00008899897,0.01503267,0.0005847595,0.0001728775,0.001708457,0.001721937,0.0001663057,0.002287141,0.00006741304],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891951,0.009142531,0.0001695052,0.00009956943,0.00003221473,0.00004229877,0.0008009183,0.00001721348,0.0005007451],"genre_scores_gemma":[0.9973079,0.001138537,0.0001142024,0.00009984582,0.00005593797,0.00002767723,0.001078471,0.000004653917,0.0001727562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003076051,"threshold_uncertainty_score":0.0162679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09173674282299754,"score_gpt":0.3838519995922673,"score_spread":0.2921152567692698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}