{"id":"W2588914509","doi":"10.1016/j.jtho.2017.01.007","title":"HER2 Transmembrane Domain Mutations: Rare New Target for Non–Small Cell Lung Cancer Therapy","year":2017,"lang":"en","type":"letter","venue":"Journal of Thoracic Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Medicine; Lung cancer; Breast cancer; ErbB; Targeted therapy; Cancer; Cancer research; Oncology; Internal medicine; Epidermal growth factor receptor; Receptor tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003837885,0.000444941,0.0008556817,0.0004029484,0.001015513,0.001256771,0.0005851784,0.01016015,0.003440127],"category_scores_gemma":[0.003405859,0.0002385785,0.0008147745,0.0002916143,0.0008889223,0.001386043,0.000556846,0.00836268,0.001700817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001358303,"about_ca_system_score_gemma":0.000715543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006230251,"about_ca_topic_score_gemma":0.00155901,"domain_scores_codex":[0.9995307,0.000102579,0.00005537753,0.0000800343,0.0001087464,0.0001225237],"domain_scores_gemma":[0.9991212,0.0004380748,0.000073034,0.00004387059,0.0001091736,0.0002146224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003408453,0.0001451644,0.01123291,0.0001773277,0.00006313512,0.6194565,0.0002438833,0.0007059469,0.004388808,0.01029815,0.3072859,0.04566151],"study_design_scores_gemma":[0.0003005468,0.0003558091,0.005285469,0.0002648417,0.0001334786,0.7016806,0.0005220614,0.004339709,0.00273607,0.02253701,0.2617804,0.00006403434],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0557001,0.0148641,0.002423314,0.8702043,0.01767354,0.000100883,0.0004270292,0.0002278173,0.03837888],"genre_scores_gemma":[0.4370336,0.01460855,0.004094203,0.426953,0.08676843,0.0001283139,0.0004931217,0.0001514803,0.02976939],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01016015,"threshold_uncertainty_score":0.01150841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06442857875986661,"score_gpt":0.4781557608819319,"score_spread":0.4137271821220653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}