{"id":"W2589012814","doi":"10.1093/neuonc/now188.231","title":"P10.07 Sialate O-acetylesterase (SIAE) 
over-expression leads to a collapse of the mitochondrial membrane potential and predisposes cells to etoposide treatment in RES256 medulloblastoma cells","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Etoposide; Medulloblastoma; Cell biology; Medicine; Chemistry; Biology; Cancer research; Molecular biology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479098,0.0003519449,0.0003482339,0.0002437155,0.0001460461,0.0002771079,0.0002507786,0.0003953573,0.003940283],"category_scores_gemma":[0.0001428028,0.0001880822,0.0004261711,0.0002657234,0.0002491712,0.0001379584,0.0001673263,0.0008351416,0.00140253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003542193,"about_ca_system_score_gemma":0.0002226551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003419992,"about_ca_topic_score_gemma":0.002279954,"domain_scores_codex":[0.9997775,0.00002801102,0.00003491082,0.00004499813,0.00006615653,0.00004841315],"domain_scores_gemma":[0.9998653,0.00002766861,0.00003121058,0.00002350248,0.00001162247,0.00004057225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001848791,0.00007457641,0.0002842259,0.00002353978,0.000007715097,0.0001866066,0.00002228942,0.00005620392,0.998297,0.00008756197,0.0001471395,0.000628198],"study_design_scores_gemma":[0.00004972688,0.001355738,0.01580103,0.00001255832,0.00002955558,0.001193673,0.0001584171,0.001526388,0.9731236,0.00006535491,0.006673213,0.000010778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920959,0.0007087481,0.001633378,0.0001912424,0.0000929427,0.00004879735,0.002694451,0.0001290278,0.002405577],"genre_scores_gemma":[0.9864477,0.0006090501,0.001293162,0.00006265376,0.000009644454,0.0000699526,0.003326634,0.00003976614,0.008141425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003940283,"threshold_uncertainty_score":0.01318157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007553555770482347,"score_gpt":0.2497022079037211,"score_spread":0.2421486521332388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}