{"id":"W2589065286","doi":"10.1182/blood.v110.11.4655.4655","title":"Familial Essential Thrombocythemia Showing Spontaneous Megakaryocyte Colony Formation and Acquired JAK2 Mutations without a Germline Mutation in C-MPL or TPO.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Essential thrombocythemia; Megakaryocyte; Thrombopoietin; Thrombopoietin receptor; Polycythemia vera; Germline mutation; Biology; Mutation; Germline; Genetics; Myeloproliferative Disorders; Immunology; Thrombocytosis; Gene; Platelet; Haematopoiesis; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002267254,0.0007410143,0.0002458568,0.0006474066,0.0007669491,0.0002038909,0.0002392674,0.0006945977,0.002627656],"category_scores_gemma":[0.0009510516,0.0002068498,0.0001986432,0.0002288961,0.0006136786,0.0001738114,0.0003624765,0.0005482053,0.0002893614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240979,"about_ca_system_score_gemma":0.0001878255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0014231,"about_ca_topic_score_gemma":0.001349605,"domain_scores_codex":[0.9997546,0.0000557943,0.00002035582,0.00005444629,0.00005734726,0.00005744622],"domain_scores_gemma":[0.999401,0.0002717311,0.00007474252,0.0000300979,0.00004953691,0.0001728926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0005235533,0.0003277122,0.1230429,0.0001300273,0.0001021591,0.7883517,0.001182674,0.0003164432,0.07589973,0.001055542,0.001445011,0.00762254],"study_design_scores_gemma":[0.0001201999,0.0005077469,0.1657869,0.00003852381,0.00009326768,0.814994,0.0002154708,0.001182111,0.01394444,0.0004361422,0.002661041,0.00002016197],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961801,0.0003147828,0.0006856687,0.0001320464,0.00002582247,0.0000257921,0.0001638574,0.00002735372,0.00244462],"genre_scores_gemma":[0.9992011,0.00007531216,0.0002003318,0.00003916033,0.00001843094,0.000005775157,0.00008961093,0.000006291759,0.0003639758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002627656,"threshold_uncertainty_score":0.008790314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835628024553921,"score_gpt":0.2928085827134607,"score_spread":0.2744523024679215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}