{"id":"W2589066064","doi":"10.3389/fonc.2017.00019","title":"Inhibition of DNA and Histone Methylation by 5-Aza-2′-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells","year":2017,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Cancer Society Research Institute","keywords":"Decitabine; Deoxycytidine; DNA methylation; Cancer research; Histone; Epigenetics; DNA; Methylation; Gene; Chemistry; Biology; Gene expression; Molecular biology; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007777085,0.0002167444,0.0001655805,0.0001351862,0.00007733784,0.0001107233,0.0001179398,0.0001175468,0.0008157347],"category_scores_gemma":[0.00006522461,0.00006528715,0.000126418,0.0001048881,0.00008163243,0.00006198585,0.0001035705,0.0002844482,0.0001326274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370898,"about_ca_system_score_gemma":0.0001655539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006155091,"about_ca_topic_score_gemma":0.001002923,"domain_scores_codex":[0.9999297,0.00001723079,0.000006310299,0.000009264602,0.00001925591,0.00001815557],"domain_scores_gemma":[0.9999725,0.000007437342,0.000005152059,0.000003081189,0.000003078061,0.000008815501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002284465,0.00004122074,0.00008787036,0.0000311464,0.000004224499,0.00004452497,0.000006812644,0.0001380461,0.9955527,0.00007797134,0.00003237543,0.00375447],"study_design_scores_gemma":[0.00004318624,0.0009745171,0.003343564,0.000004375478,0.000008930608,0.0002512547,0.000009052845,0.0008958288,0.9910671,0.00003591817,0.003363633,0.000002513285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909782,0.004636363,0.001614879,0.00006456293,0.00003126022,0.00003992741,0.0001875402,0.00003972618,0.002407529],"genre_scores_gemma":[0.9951047,0.001911621,0.001149046,0.00003115722,0.00000775055,0.00003639793,0.0002549443,0.000004237876,0.001500231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008157347,"threshold_uncertainty_score":0.002728939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225063193565877,"score_gpt":0.2846255991568978,"score_spread":0.272374967221239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}