{"id":"W2589066064","doi":"10.3389/fonc.2017.00019","title":"Inhibition of DNA and Histone Methylation by 5-Aza-2′-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells","year":2017,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Cancer Society Research Institute","keywords":"Decitabine; Deoxycytidine; DNA methylation; Cancer research; Histone; Epigenetics; DNA; Methylation; Gene; Chemistry; Biology; Gene expression; Molecular biology; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003193365,0.0001396101,0.0002611136,0.0001496434,0.00008530642,0.0000147128,0.00005526629,0.0002927588,0.000002020733],"category_scores_gemma":[0.0001431094,0.0001445137,0.00001723104,0.00003698254,0.0001637906,0.00001576803,0.00007927271,0.0001177401,2.275581e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006634973,"about_ca_system_score_gemma":0.00003917174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005769043,"about_ca_topic_score_gemma":0.00006185664,"domain_scores_codex":[0.9990156,0.0001091241,0.0002796994,0.0003590639,0.00007993562,0.0001565317],"domain_scores_gemma":[0.9994189,0.00004251655,0.0002593025,0.0001943667,0.00003138465,0.00005354291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003243414,0.00005389965,0.02119375,0.00003125387,0.000006888829,0.000003400944,0.0001094218,0.00004994309,0.9646248,0.000003728767,0.0003767443,0.01322184],"study_design_scores_gemma":[0.00186662,0.0005941582,0.05495792,0.00003790566,0.00001216918,0.000004579334,0.0000730027,0.0004234784,0.9403067,0.0003080866,0.001279115,0.0001362576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932011,0.002888518,0.003016282,0.000095547,0.0003670091,0.0002012579,0.00001932826,0.00000327094,0.0002077256],"genre_scores_gemma":[0.9911371,0.005127362,0.00344772,0.00002102505,0.00006606642,0.00001214262,0.00009056118,0.00001429411,0.00008368786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03376416,"threshold_uncertainty_score":0.5893099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225063193565877,"score_gpt":0.2846255991568978,"score_spread":0.272374967221239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}