{"id":"W2589069501","doi":"10.1182/blood.v110.11.892.892","title":"A Phase I Trial of the Small Molecule Pan-Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) Administered by Continuous Infusion for up to Four Days to Patients with Hematological Malignancies.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chills; Neutropenia; Internal medicine; Febrile neutropenia; Nausea; Tolerability; Gastroenterology; Adverse effect; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006074216,0.0002952529,0.0006895451,0.0001189121,0.0001001861,0.00002796683,0.0003475377,0.0002099037,0.00001583943],"category_scores_gemma":[0.001073966,0.0001811366,0.0001838765,0.000458545,0.0001122665,0.0000347062,0.0002640159,0.0001816382,0.00001769637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008885055,"about_ca_system_score_gemma":0.001924329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001164899,"about_ca_topic_score_gemma":0.00006235914,"domain_scores_codex":[0.9970939,0.00007271266,0.0007178391,0.0005283755,0.0008552792,0.0007319251],"domain_scores_gemma":[0.9979311,0.0002938297,0.0002003934,0.0006949324,0.0004386648,0.0004410797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5304697,0.03194394,0.007245265,0.001385373,0.001033254,0.0007966378,0.004009408,0.000002999451,0.3715655,0.0003182688,0.02964471,0.02158498],"study_design_scores_gemma":[0.6766665,0.01916335,0.001034332,0.0005256021,0.0003137393,0.00008459404,0.0002334016,0.0000438648,0.2954584,0.00001398621,0.00610504,0.0003571647],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991822,0.00009491105,0.0005462207,0.0002219141,0.0002444956,0.006459877,0.000138962,0.00004960189,0.0004220149],"genre_scores_gemma":[0.996909,0.000005343392,0.00102572,0.0007031662,0.0001418284,0.000287941,0.00004335178,0.00005257718,0.0008311125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1461968,"threshold_uncertainty_score":0.7386534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961598884825406,"score_gpt":0.2986831450077576,"score_spread":0.2690671561595035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}