{"id":"W2589069501","doi":"10.1182/blood.v110.11.892.892","title":"A Phase I Trial of the Small Molecule Pan-Bcl-2 Family Inhibitor Obatoclax Mesylate (GX15-070) Administered by Continuous Infusion for up to Four Days to Patients with Hematological Malignancies.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chills; Neutropenia; Internal medicine; Febrile neutropenia; Nausea; Tolerability; Gastroenterology; Adverse effect; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006875729,0.001533954,0.001112351,0.0004611458,0.00038504,0.0005324467,0.0006328935,0.0007940279,0.003595777],"category_scores_gemma":[0.000433946,0.0004356517,0.0006950165,0.0002881481,0.0008546501,0.0007163983,0.0004270477,0.002539937,0.0008081695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005330578,"about_ca_system_score_gemma":0.000846112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006652558,"about_ca_topic_score_gemma":0.001454115,"domain_scores_codex":[0.9998084,0.00007857357,0.000007900588,0.00003605101,0.00001840538,0.00005085981],"domain_scores_gemma":[0.9996778,0.00005081371,0.00005593219,0.00003096189,0.0000172106,0.0001674391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5820723,0.08250125,0.00820182,0.0008357219,0.0007153777,0.0006718251,0.0005417766,0.004463302,0.1011094,0.001294267,0.00793921,0.2096538],"study_design_scores_gemma":[0.402049,0.5721451,0.01099278,0.00003595331,0.0001900437,0.0005017268,0.00008112749,0.001592787,0.006806099,0.0004483964,0.005124649,0.00003230194],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917545,0.001349799,0.0006648073,0.0003880889,0.0001193261,0.002298707,0.0006566339,0.00008384695,0.002684336],"genre_scores_gemma":[0.9859194,0.001836825,0.001902708,0.0008600066,0.0001346221,0.002620615,0.002421752,0.00002268557,0.004281586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003595777,"threshold_uncertainty_score":0.01202905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961598884825406,"score_gpt":0.2986831450077576,"score_spread":0.2690671561595035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}