{"id":"W2589070781","doi":"10.1093/annonc/mdw375.43","title":"Phase 3 study of quizartinib (AC220) monotherapy vs salvage chemotherapy (SC) in patients (pts) with FLT3-ITD+ acute myeloid leukemia (AML) refractory to or relapsed (R/R) after 1st-line treatment with or without hematopoietic stem cell transplant (HSCT) consolidation: the QuANTUM-R study","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Medicine; Cytarabine; Internal medicine; Mitoxantrone; Idarubicin; Oncology; Salvage therapy; Phases of clinical research; Febrile neutropenia; Etoposide; Chemotherapy regimen; Myeloid leukemia; Chemotherapy; Surgery; Neutropenia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001115125,0.001117445,0.00261696,0.0003520575,0.0003353166,0.001032893,0.0008824365,0.0008423561,0.003551345],"category_scores_gemma":[0.0008895051,0.0004649575,0.00168001,0.0004438292,0.001136313,0.0008738983,0.0003712044,0.002758168,0.0007397837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001173179,"about_ca_system_score_gemma":0.001709214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002029751,"about_ca_topic_score_gemma":0.005774757,"domain_scores_codex":[0.9997216,0.0001331759,0.00001016038,0.00005829199,0.00001863334,0.00005817902],"domain_scores_gemma":[0.9993813,0.0001151053,0.0001059888,0.00006061894,0.00003027409,0.0003066087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9151618,0.0236136,0.002771098,0.0004244999,0.001318794,0.00008409136,0.0001369206,0.002246523,0.01221326,0.0003812972,0.002744247,0.03890385],"study_design_scores_gemma":[0.7516801,0.234308,0.00853723,0.0000244358,0.0008185753,0.0001166665,0.00006167892,0.00135334,0.001115317,0.0004579426,0.001490606,0.00003606614],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947286,0.0009408433,0.0003433867,0.0003874707,0.0001208479,0.001023459,0.001070141,0.00007257296,0.001312637],"genre_scores_gemma":[0.9922627,0.001153241,0.001218766,0.0007152464,0.0001402304,0.001009549,0.001828193,0.00003219641,0.001639797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003551345,"threshold_uncertainty_score":0.0118804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05300243935670836,"score_gpt":0.3718103538949401,"score_spread":0.3188079145382318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}