{"id":"W2589078350","doi":"10.1182/blood.v118.21.385.385","title":"A Functional In Vivo RNAi screen Involving Jumonji C Domain Containing Candidates Unravels Kdm5b As a Negative Modulator of Hematopoietic Stem Cell Self-Renewal","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McMaster University; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Biology; Stem cell; Haematopoiesis; Small hairpin RNA; Hematopoietic stem cell; H3K4me3; Molecular biology; Cell biology; Transplantation; RNA interference; Bone marrow; Cell culture; Gene expression; Gene knockdown; Gene; Genetics; Immunology; RNA; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093054,0.0004069553,0.0003372843,0.0003265556,0.0001687066,0.000216197,0.0002797454,0.0002498542,0.0013232],"category_scores_gemma":[0.00007316736,0.0001749285,0.0002311035,0.0001920167,0.0001940791,0.00007134808,0.0001456997,0.0003132268,0.0004509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689494,"about_ca_system_score_gemma":0.0001519314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005144202,"about_ca_topic_score_gemma":0.001438802,"domain_scores_codex":[0.9998822,0.00001754984,0.00001389075,0.00002654745,0.00004155907,0.000018176],"domain_scores_gemma":[0.9998775,0.00003309232,0.00003498911,0.00001255539,0.00001033044,0.00003147142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002033862,0.000007864181,0.00006180421,0.00001210135,0.000002045173,0.00001998411,0.000002654167,0.00002145058,0.9995889,0.00001749217,0.00001377717,0.000231564],"study_design_scores_gemma":[0.00001978719,0.0001769707,0.004350754,0.000005541338,0.00003038203,0.0001444935,0.00001719605,0.001187989,0.9921261,0.00001666018,0.00192028,0.000003833789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896603,0.0009686094,0.005630844,0.0000891189,0.00002889093,0.00009608704,0.001846459,0.0001751709,0.001504516],"genre_scores_gemma":[0.987285,0.0005881322,0.005070065,0.00008520022,0.000008212255,0.00007239253,0.002863205,0.00007124314,0.003956654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013232,"threshold_uncertainty_score":0.004426539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393246731991403,"score_gpt":0.2139813846898125,"score_spread":0.2000489173698984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}