{"id":"W2589079421","doi":"10.1093/ndt/gfw168.01","title":"SP374CANAGLIFLOZIN, A SODIUM-GLUCOSE CO-TRANSPORTER 2 (SGLT-2) BLOCKER, NORMALIZES BLOOD GLUCOSE WITHOUT AFFECTING SYSTEMIC BLOOD PRESSURE, OXIDATIVE STRESS, INTRARENAL ANGIOTENSINOGEN GENE EXPRESSION AND KIDNEY INJURY IN TYPE 1 DIABETIC MICE","year":2016,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Oxidative stress; Blood pressure; Internal medicine; Endocrinology; Type 2 diabetes; Transporter; Diabetes mellitus; Kidney; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112622,0.0005670513,0.0007469092,0.0007698917,0.00018659,0.0003618464,0.0003527521,0.0004781131,0.001855965],"category_scores_gemma":[0.0001072383,0.000240751,0.0004459186,0.0003773736,0.0003173678,0.0003025228,0.0001544236,0.001271439,0.0003692551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758684,"about_ca_system_score_gemma":0.0003383481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000627502,"about_ca_topic_score_gemma":0.001330579,"domain_scores_codex":[0.9997302,0.00002599677,0.00003717366,0.00006135397,0.00007962899,0.000065621],"domain_scores_gemma":[0.9996961,0.00001671998,0.0001371846,0.00002748537,0.00002986501,0.00009254585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001363497,0.0005526071,0.0005447461,0.00008264502,0.00002661173,0.00003455433,0.0000149282,0.00008896882,0.9926157,0.00005709975,0.0002175955,0.00440098],"study_design_scores_gemma":[0.0005225514,0.00516249,0.01312542,0.00002459801,0.0001402491,0.0003505912,0.00004365183,0.002055829,0.9750195,0.00007513556,0.003462907,0.00001703162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992053,0.001174537,0.003557689,0.0002096592,0.0001016474,0.00007251219,0.001018152,0.0006560049,0.001156777],"genre_scores_gemma":[0.979529,0.001940349,0.01001786,0.000353352,0.00008776287,0.0003569831,0.0023179,0.0001465284,0.005250276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855965,"threshold_uncertainty_score":0.006208837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006329337626800737,"score_gpt":0.2283097065883897,"score_spread":0.2219803689615889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}