{"id":"W2589094768","doi":"10.3390/molecules22020276","title":"Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Population and Public Health; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; King Saud University; National Research Foundation","keywords":"PTEN; STAT3; Phosphorylation; STAT protein; Phosphatase; Cancer research; Protein tyrosine phosphatase; Tyrosine phosphorylation; Biology; Signal transduction; Transcription factor; Kinase; Chemistry; Cell biology; Biochemistry; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005450876,0.0001622112,0.0002834456,0.00007247835,0.0002621106,0.00007925188,0.00006863476,0.00009563009,0.00008878613],"category_scores_gemma":[0.0002941173,0.0001425716,0.00003705465,0.00005548775,0.0004103224,0.0004685391,0.00008328338,0.0001732678,0.000002732265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002684383,"about_ca_system_score_gemma":0.00007910538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00244888,"about_ca_topic_score_gemma":0.00005570469,"domain_scores_codex":[0.9991593,0.00002392917,0.0002164763,0.0003090072,0.0001445826,0.0001467544],"domain_scores_gemma":[0.9991384,0.00005217723,0.0002309951,0.0003628989,0.0001377618,0.00007778931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002272168,0.0001124227,0.003166217,0.00004402978,0.0001147377,0.00001200286,0.0007036401,0.000004930124,0.9894938,0.001403977,0.001055931,0.003661036],"study_design_scores_gemma":[0.00132058,0.0001849859,0.05488814,0.0003014475,0.0001179237,0.00002336168,0.0004088928,0.00007452314,0.9392752,0.0006350512,0.002640592,0.0001292947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932443,0.001220816,0.002377142,0.001061786,0.0001359912,0.0002620888,0.0003393494,0.00003280911,0.001325658],"genre_scores_gemma":[0.996855,0.0003716161,0.002191592,0.0001898682,0.00009843239,0.00001444026,0.0002180172,0.00001560941,0.00004543928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05172192,"threshold_uncertainty_score":0.5813903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209672520193936,"score_gpt":0.3016214503021118,"score_spread":0.2595247251001724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}