{"id":"W2589094768","doi":"10.3390/molecules22020276","title":"Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Population and Public Health; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; King Saud University; National Research Foundation","keywords":"PTEN; STAT3; Phosphorylation; STAT protein; Phosphatase; Cancer research; Protein tyrosine phosphatase; Tyrosine phosphorylation; Biology; Signal transduction; Transcription factor; Kinase; Chemistry; Cell biology; Biochemistry; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006049983,0.0004804584,0.000252731,0.0003259948,0.0001077503,0.0001266042,0.0001319777,0.0001950553,0.0006482658],"category_scores_gemma":[0.00005345145,0.00009995928,0.000243389,0.0002147284,0.0002053221,0.0001086656,0.0001523267,0.0004668294,0.0001672595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002461958,"about_ca_system_score_gemma":0.0002870746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007743926,"about_ca_topic_score_gemma":0.001144722,"domain_scores_codex":[0.9999365,0.000008699514,0.000005998502,0.00001019342,0.00001547635,0.00002320609],"domain_scores_gemma":[0.9999602,0.000004138218,0.00001481833,0.000003451539,0.000003498191,0.00001402962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001634954,0.00002489536,0.00009655559,0.00002891404,0.000004028682,0.00002713727,0.000004510313,0.00003220142,0.9989861,0.00002976858,0.00001928123,0.0005830294],"study_design_scores_gemma":[0.00004253272,0.0004145545,0.003057598,0.000004118725,0.00002864854,0.0001513425,0.00001218152,0.0004875206,0.9941068,0.00003385288,0.001657678,0.00000308585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963168,0.001311152,0.001265617,0.00007423913,0.00002650597,0.0000234519,0.0003233328,0.00008869269,0.0005702615],"genre_scores_gemma":[0.9958518,0.0009376305,0.001156606,0.00005096256,0.000006911841,0.00003357332,0.0006304952,0.00002478447,0.001307293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007743926,"threshold_uncertainty_score":0.002168655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209672520193936,"score_gpt":0.3016214503021118,"score_spread":0.2595247251001724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}