{"id":"W2589106972","doi":"10.1093/neuonc/now212.327","title":"GENT-21. ATRX DEFICIENCY PROMOTES INVASION AND ALTERS THE DIFFERENTIATION CAPACITY OF GLIOMA CELLS OF ORIGIN BY DYSREGULATING GENOME-WIDE CHROMATIN ACCESSIBILITY AND MODULATING TRANSCRIPTIONAL PROGRAMS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Biology; Chromatin; Genome instability; Epigenetics; Carcinogenesis; Cell biology; Cancer research; Genetics; Gene; Mutation; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002930305,0.0001363524,0.0002065343,0.00002704845,0.0000920088,0.00001176789,0.0001213871,0.0001110924,0.000007277847],"category_scores_gemma":[0.00009943773,0.0000878975,0.00005418243,0.00006827553,0.0002809628,0.00001260921,0.00007606891,0.00006457506,1.530187e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002985503,"about_ca_system_score_gemma":0.000063539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003829627,"about_ca_topic_score_gemma":0.0000356856,"domain_scores_codex":[0.9987542,0.0001807783,0.0003915531,0.0003514523,0.0001441122,0.0001779234],"domain_scores_gemma":[0.9992645,0.0001023549,0.0003025713,0.0001984404,0.00008381231,0.00004835312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004551296,0.00008675802,0.02181776,0.0001031739,0.00001373239,2.500713e-7,0.0002492101,0.0000270659,0.9597167,0.00001435132,0.00001037108,0.01791509],"study_design_scores_gemma":[0.0009028827,0.0006292796,0.04154123,0.00004196683,0.00003541469,0.00001621939,0.00007342664,0.00272262,0.9535394,0.0002352416,0.0001367674,0.0001255097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947321,0.0003615212,0.004230144,0.0001988571,0.00007698777,0.0003355199,0.00002928344,0.000009142603,0.00002640721],"genre_scores_gemma":[0.9986297,0.00008573689,0.001146792,0.00003657568,0.00004028262,0.00001976665,0.0000239267,0.00001233037,0.000004929004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01972347,"threshold_uncertainty_score":0.3584356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231008421553646,"score_gpt":0.2589544808320386,"score_spread":0.235853638676674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}