{"id":"W2589106972","doi":"10.1093/neuonc/now212.327","title":"GENT-21. ATRX DEFICIENCY PROMOTES INVASION AND ALTERS THE DIFFERENTIATION CAPACITY OF GLIOMA CELLS OF ORIGIN BY DYSREGULATING GENOME-WIDE CHROMATIN ACCESSIBILITY AND MODULATING TRANSCRIPTIONAL PROGRAMS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Biology; Chromatin; Genome instability; Epigenetics; Carcinogenesis; Cell biology; Cancer research; Genetics; Gene; Mutation; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009825968,0.000435078,0.0003158215,0.0003622521,0.0001652168,0.0002698682,0.0002026847,0.0003043512,0.002805129],"category_scores_gemma":[0.00007468402,0.0001775278,0.0003315172,0.0001957904,0.0002283958,0.0001388347,0.0002397317,0.0007459625,0.0007680166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992692,"about_ca_system_score_gemma":0.000313912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398634,"about_ca_topic_score_gemma":0.002920201,"domain_scores_codex":[0.9998187,0.00003535116,0.00001921778,0.0000282297,0.00004605202,0.00005244881],"domain_scores_gemma":[0.9998878,0.00001819361,0.00002286604,0.00001626376,0.000007454016,0.0000473037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000172886,0.00009206912,0.0001235086,0.00002754766,0.00000710559,0.00009021338,0.00002197284,0.00008389995,0.9978184,0.0001647495,0.0001154394,0.00128226],"study_design_scores_gemma":[0.00002851705,0.0007947391,0.00322634,0.000006521243,0.00002305293,0.0003424695,0.00002053865,0.0008360328,0.9895318,0.00007401311,0.005110588,0.000005429779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899983,0.001608447,0.001408622,0.0001920254,0.00005865243,0.00004867709,0.0009267399,0.0002959904,0.005462502],"genre_scores_gemma":[0.983648,0.001181431,0.001895721,0.0001163885,0.00001217553,0.00005952985,0.002361377,0.00006227773,0.01066305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002805129,"threshold_uncertainty_score":0.009384155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231008421553646,"score_gpt":0.2589544808320386,"score_spread":0.235853638676674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}