{"id":"W2589109655","doi":"10.1038/s41467-016-0008-7","title":"CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Government of Canada","keywords":"Exon; RNA splicing; Gene; Gene knockdown; Biology; Alternative splicing; SR protein; Genetics; RNA recognition motif; RNA-binding protein; RNA; Splicing factor; Intron; Kinase; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328679,0.0003267674,0.0001932183,0.0001536153,0.0001403959,0.0001860311,0.0002698046,0.0002384078,0.001037031],"category_scores_gemma":[0.0001043646,0.0001191101,0.0002561935,0.000110975,0.0001889091,0.0001269832,0.0001572636,0.0004571102,0.0002665229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705403,"about_ca_system_score_gemma":0.0001985223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002992044,"about_ca_topic_score_gemma":0.0007373576,"domain_scores_codex":[0.9998904,0.00001340052,0.000009643662,0.00003802292,0.0000279438,0.00002061099],"domain_scores_gemma":[0.9999352,0.00001501174,0.00001883503,0.000009327474,0.000006704387,0.00001498785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007157349,0.00001995569,0.00006292146,0.00002741081,0.000003854505,0.00003563279,0.000004664894,0.0000939797,0.9983827,0.0001204743,0.00003575521,0.001141216],"study_design_scores_gemma":[0.00001310084,0.00009242112,0.0003309604,0.000001510796,0.000004452298,0.00006435786,0.000002609336,0.0007972405,0.9976187,0.00001848766,0.001054215,0.000002058611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721095,0.002151359,0.02105086,0.000226196,0.00008039724,0.0001179553,0.0004809219,0.0002567305,0.003525978],"genre_scores_gemma":[0.9856358,0.0009306761,0.009521597,0.00012317,0.00001117527,0.0001109131,0.0004136083,0.00003279449,0.003220354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037031,"threshold_uncertainty_score":0.003469229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04152963638410137,"score_gpt":0.3000557458856283,"score_spread":0.258526109501527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}