{"id":"W2589138491","doi":"10.1038/srep42957","title":"Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Brock University; University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitochondrion; Apoptosis; Cancer cell; Oxidative phosphorylation; Cell biology; Cancer; Biology; In vivo; Cancer research; Function (biology); Intrinsic apoptosis; Programmed cell death; Chemistry; Biochemistry; Caspase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002806375,0.0001689543,0.0002007504,0.00002294276,0.001596821,0.0004924412,0.0001576397,0.00008015323,0.007880609],"category_scores_gemma":[0.0000725115,0.0001472668,0.00007227065,0.00004286182,0.0002388255,0.0001347764,0.0001676819,0.0001280557,0.000009655373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006235717,"about_ca_system_score_gemma":0.00004452038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007079857,"about_ca_topic_score_gemma":0.00008459744,"domain_scores_codex":[0.9980001,0.000007104115,0.0003833632,0.0008204621,0.0005020425,0.0002868782],"domain_scores_gemma":[0.9985301,0.0000370125,0.0004656255,0.0007258482,0.00008134596,0.0001600115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000724689,0.00005445011,0.004100381,0.00002388446,0.00001067264,0.00002384648,0.00006389212,0.000001434442,0.6929761,0.000004825447,0.3015629,0.001170341],"study_design_scores_gemma":[0.0002199869,0.000006083308,0.0007900326,0.00004898404,0.00001930851,0.00001377948,0.00007984761,0.0001388652,0.8738784,0.0005845837,0.1240073,0.0002128718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762422,0.0004051977,0.00002529307,0.0002742803,0.001476089,0.00006410966,0.00008074154,0.00003283561,0.02139925],"genre_scores_gemma":[0.9652382,0.00002785755,0.0001884746,0.00006622588,0.0001778161,0.00002415381,0.0001665826,0.00001497258,0.03409575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1809023,"threshold_uncertainty_score":0.999703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894919454196136,"score_gpt":0.2520851241385014,"score_spread":0.2331359295965401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}