{"id":"W2589138491","doi":"10.1038/srep42957","title":"Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Brock University; University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitochondrion; Apoptosis; Cancer cell; Oxidative phosphorylation; Cell biology; Cancer; Biology; In vivo; Cancer research; Function (biology); Intrinsic apoptosis; Programmed cell death; Chemistry; Biochemistry; Caspase; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006703955,0.0002027817,0.0001729142,0.00009055821,0.00008623256,0.0001759573,0.0001291096,0.0001339642,0.0006082777],"category_scores_gemma":[0.00007743215,0.00007137952,0.0001136896,0.00009944436,0.000102552,0.0001695088,0.000108348,0.0002889531,0.0002322794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123477,"about_ca_system_score_gemma":0.0001804392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002633498,"about_ca_topic_score_gemma":0.0009780914,"domain_scores_codex":[0.9999449,0.000009518178,0.000005587971,0.000010996,0.00001853116,0.0000104364],"domain_scores_gemma":[0.9999455,0.000007978409,0.00001977172,0.000007473281,0.000009715784,0.000009489887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007320373,0.00001090371,0.00009117331,0.00003827666,0.000003109567,0.0000388886,0.000007859049,0.000139425,0.9969362,0.0001292054,0.0000363466,0.002495472],"study_design_scores_gemma":[0.0000178879,0.0004299657,0.001333636,0.000003989262,0.000009644266,0.0002852708,0.000008124431,0.000413207,0.993985,0.00004830017,0.003462143,0.000002878421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871798,0.002853517,0.003487187,0.0001418352,0.00002233961,0.00006465543,0.0004346912,0.00009894474,0.005717081],"genre_scores_gemma":[0.9942145,0.001438548,0.002437125,0.00004572385,0.000005362199,0.00001954637,0.0003420874,0.00001595548,0.001481315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006082777,"threshold_uncertainty_score":0.002034843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894919454196136,"score_gpt":0.2520851241385014,"score_spread":0.2331359295965401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}