{"id":"W2589149922","doi":"10.1182/blood.v128.22.1073.1073","title":"A Phase I Study of IDH305 in Patients with Advanced Malignancies Including Relapsed/Refractory AML and MDS That Harbor IDH1R132 Mutations","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Isocitrate dehydrogenase; IDH1; Tolerability; Medicine; Population; Myeloid leukemia; Glioma; Myelodysplastic syndromes; Pharmacology; Cancer research; Internal medicine; Oncology; Adverse effect; Biology; Mutation; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00103509,0.001271377,0.001346411,0.0003076275,0.0003449791,0.0005852635,0.0006345126,0.000731647,0.002355704],"category_scores_gemma":[0.0004100349,0.0004439989,0.0008679446,0.0003186387,0.0006618425,0.0004506359,0.0002969084,0.002158835,0.0006453508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007505947,"about_ca_system_score_gemma":0.001487637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203608,"about_ca_topic_score_gemma":0.003335431,"domain_scores_codex":[0.9997881,0.0000727357,0.00001043094,0.00004225181,0.00002854478,0.00005781132],"domain_scores_gemma":[0.9996361,0.00004480482,0.0000428433,0.00002981134,0.00002221725,0.0002242808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5777769,0.1160034,0.0178684,0.001552918,0.001565384,0.0009418922,0.0008548607,0.006478206,0.1212593,0.001008654,0.007516416,0.1471736],"study_design_scores_gemma":[0.3309088,0.6365855,0.01949389,0.00003851916,0.0004169411,0.0006502342,0.0001162703,0.001640175,0.005858962,0.0003454135,0.003905613,0.00003957763],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934387,0.001159009,0.0005873349,0.0002809562,0.00008009107,0.002049345,0.0007598453,0.00007509874,0.001569666],"genre_scores_gemma":[0.9938599,0.0008085229,0.001114059,0.0004411267,0.00007112969,0.001198925,0.001255275,0.0000113099,0.001239841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355704,"threshold_uncertainty_score":0.007880569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967998147081014,"score_gpt":0.2768842672032304,"score_spread":0.2572042857324203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}