{"id":"W2589191412","doi":"10.1074/jbc.m116.768374","title":"Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Pfizer UK; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Ontario Genomics; Genome Canada; University of Chicago; Ontario Genomics Institute; Canadian Institutes of Health Research; Wellcome; Biological and Environmental Research; National Natural Science Foundation of China; Takeda Science Foundation; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Argonne National Laboratory; U.S. Department of Energy","keywords":"Heterochromatin protein 1; Histone; Histone H3; Heterochromatin; Biology; Cell biology; Genetics; Chemistry; Chromatin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053914,0.0001065715,0.0001387769,0.00009142205,0.0001307517,0.0002708913,0.0002182847,0.0002475485,0.0009151192],"category_scores_gemma":[0.0001456017,0.0001300341,0.0001438083,0.00009605505,0.0002738099,0.0003275068,0.0002146901,0.0002308214,0.0002531472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721784,"about_ca_system_score_gemma":0.00007432715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002848836,"about_ca_topic_score_gemma":0.0003448374,"domain_scores_codex":[0.9999486,0.000007769871,0.000002353488,0.0000179126,0.00001362586,0.000009747461],"domain_scores_gemma":[0.9999466,0.00001787816,0.00001452716,0.000005416837,0.000004667624,0.00001094197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001453669,0.000008638605,0.002070384,0.00004890329,0.000009513338,0.000183785,0.00006458621,0.0007643464,0.9921924,0.001015426,0.00006553401,0.003431134],"study_design_scores_gemma":[0.00008060057,0.0004454588,0.09555434,0.00002554605,0.00005319062,0.002671377,0.0004123899,0.02018862,0.8705914,0.003519362,0.006411149,0.00004644264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968649,0.0006673245,0.001650922,0.00006237898,0.000005237907,0.000002546071,0.00002049899,0.00001888313,0.0007073432],"genre_scores_gemma":[0.9988514,0.0002438267,0.0005255964,0.0000370956,0.000004423243,0.000002453721,0.00003013424,0.000003855911,0.0003012989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009151192,"threshold_uncertainty_score":0.003061354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996026110256688,"score_gpt":0.2694084213625715,"score_spread":0.2494481602600047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}