{"id":"W2589247936","doi":"10.4088/jcp.15m10286","title":"Switching to Clozapine Using Immediate Versus Gradual Antipsychotic Discontinuation","year":2017,"lang":"en","type":"article","venue":"The Journal of Clinical Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Discontinuation; Clozapine; Brief Psychiatric Rating Scale; Schizoaffective disorder; Tolerability; Antipsychotic; Psychology; Schizophrenia (object-oriented programming); Randomized controlled trial; Extrapyramidal symptoms; Internal medicine; Rating scale; Psychiatry; Medicine; Psychosis; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009910597,0.0007695528,0.001336591,0.0003039553,0.0001775481,0.0005371719,0.0004057466,0.0006548729,0.001955415],"category_scores_gemma":[0.002343355,0.0002768333,0.0008374717,0.0002278497,0.0003787361,0.0003595883,0.0002712547,0.0009925077,0.0001769127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003001785,"about_ca_system_score_gemma":0.0004838043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005540652,"about_ca_topic_score_gemma":0.001671946,"domain_scores_codex":[0.9993913,0.000245596,0.00007601879,0.0001021649,0.00009145234,0.00009342503],"domain_scores_gemma":[0.9984865,0.0005696028,0.0005327335,0.00006808474,0.00004009143,0.0003029007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8279593,0.01555838,0.01083997,0.001237933,0.001852932,0.0001412188,0.0001698646,0.0009932729,0.00742118,0.00006757283,0.0002233031,0.1335351],"study_design_scores_gemma":[0.3705655,0.5821844,0.04230637,0.0001562222,0.001162112,0.0001686942,0.0001015726,0.0008456982,0.001764615,0.0001012961,0.0006076192,0.00003583281],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997214,0.001822722,0.0001369854,0.00004908072,0.00004396434,0.0003103453,0.00005814999,0.00001779777,0.0003469604],"genre_scores_gemma":[0.9980306,0.0008604442,0.0003687334,0.00008904646,0.0001182379,0.000305969,0.00006819295,0.000002267356,0.0001565675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955415,"threshold_uncertainty_score":0.00654155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2122396456174229,"score_gpt":0.5126830430636746,"score_spread":0.3004433974462517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}