{"id":"W2589278720","doi":"10.1534/g3.116.038117","title":"Genome-Wide Screen Reveals <i>sec21</i> Mutants of <i>Saccharomyces cerevisiae</i> Are Methotrexate-Resistant","year":2017,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Aeronautics and Space Administration","keywords":"Saccharomyces cerevisiae; Dihydrofolate reductase; Drug resistance; Biology; Mutation; Methotrexate; Drug; Mechanism (biology); Computational biology; Genetics; Yeast; Pharmacology; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940234,0.000504402,0.0004417249,0.0004659522,0.0002865212,0.0005444885,0.0002887655,0.0004125947,0.001584894],"category_scores_gemma":[0.0001531274,0.0001755352,0.0007626059,0.0006104806,0.0001997735,0.0001073665,0.0002569804,0.0004890509,0.0007380887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523568,"about_ca_system_score_gemma":0.0001919511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001713003,"about_ca_topic_score_gemma":0.003133469,"domain_scores_codex":[0.999815,0.00001938773,0.00002071859,0.00006333718,0.00005814342,0.00002333527],"domain_scores_gemma":[0.9998441,0.00002696094,0.00004926562,0.00002065003,0.00002598013,0.00003308809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651867,0.00002746659,0.003323002,0.0000886062,0.00005935184,0.0003612906,0.00002340444,0.0001201905,0.9931293,0.00009740744,0.0003723904,0.002232454],"study_design_scores_gemma":[0.0000656781,0.0005175199,0.1503256,0.00004815517,0.0004768685,0.002395779,0.0003315354,0.004766421,0.8170227,0.0001816291,0.02379615,0.00007189614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785606,0.002292695,0.004616745,0.0002740632,0.00008232999,0.00006467458,0.01128451,0.0007234373,0.00210097],"genre_scores_gemma":[0.9816296,0.001068156,0.003598148,0.0002774814,0.00001302134,0.00002988615,0.01124528,0.0001360074,0.002002472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713003,"threshold_uncertainty_score":0.005301952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0258711081295622,"score_gpt":0.2934833411937143,"score_spread":0.2676122330641522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}