{"id":"W2589361283","doi":"10.1016/j.psyneuen.2017.02.020","title":"Biomarker development: Current issues and perspectives","year":2017,"lang":"en","type":"letter","venue":"Psychoneuroendocrinology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Amygdala; Biomarker; Anxiety; Depression (economics); Mood; Psychology; Inflammation; Clinical psychology; Peripheral; Internal medicine; Medicine; Psychiatry; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03511057,0.000989872,0.002705112,0.001763628,0.002409017,0.008870605,0.003295931,0.01981515,0.005514478],"category_scores_gemma":[0.07738771,0.0006459256,0.001235257,0.0013273,0.007800363,0.01446308,0.004187061,0.01907618,0.003323767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003432859,"about_ca_system_score_gemma":0.008960381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002068848,"about_ca_topic_score_gemma":0.00388736,"domain_scores_codex":[0.9866548,0.005821518,0.002449246,0.001457538,0.002850187,0.000766757],"domain_scores_gemma":[0.9022195,0.06402759,0.004262992,0.002336574,0.0222021,0.004951308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004768171,0.0002397155,0.006439251,0.002037844,0.0001168634,0.0030542,0.0004021574,0.0006046525,0.0008487164,0.04813141,0.5483092,0.3893392],"study_design_scores_gemma":[0.0002273468,0.0003455247,0.002054748,0.005023246,0.0001777914,0.005376692,0.00136725,0.001922275,0.0009304441,0.1820061,0.8004215,0.0001471695],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005492435,0.09311176,0.001877333,0.8859242,0.01624731,0.00001684995,0.00009625781,0.00005415333,0.002122869],"genre_scores_gemma":[0.02952377,0.1581003,0.01152621,0.6064243,0.1904352,0.0001831836,0.0004162913,0.00006947836,0.003321416],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03511057,"threshold_uncertainty_score":0.1856846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0914514605337021,"score_gpt":0.3391176875780616,"score_spread":0.2476662270443595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}