{"id":"W2589361283","doi":"10.1016/j.psyneuen.2017.02.020","title":"Biomarker development: Current issues and perspectives","year":2017,"lang":"en","type":"letter","venue":"Psychoneuroendocrinology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Amygdala; Biomarker; Anxiety; Depression (economics); Mood; Psychology; Inflammation; Clinical psychology; Peripheral; Internal medicine; Medicine; Psychiatry; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00002864173,0.0005698237,0.0005147055,0.0004050166,0.0004937954,0.0001965581,0.0009800334,0.0002148843,0.0002202445],"category_scores_gemma":[0.0004363743,0.0005381368,0.000112183,0.00009850589,0.0009712579,0.0001509591,0.0003243444,0.001696638,0.0005504073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002973616,"about_ca_system_score_gemma":0.00006726578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009200926,"about_ca_topic_score_gemma":0.000003809547,"domain_scores_codex":[0.9964645,0.0003088153,0.000332302,0.001619092,0.0003191257,0.000956199],"domain_scores_gemma":[0.9984443,0.0002156031,0.0002905237,0.0009232493,0.00004019884,0.00008618024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002826904,0.00007630864,0.00009493664,0.0001102123,0.00002196498,0.001336387,0.0003891639,1.38839e-8,0.0017892,0.0003154279,0.9547375,0.04110062],"study_design_scores_gemma":[0.0005748708,0.0000456315,0.003422815,0.00004094199,0.00001091261,0.0007099871,0.00002591206,0.000001965647,0.00236094,0.0007808813,0.9915198,0.0005053137],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01156979,0.01264591,0.00002297976,0.9593567,0.005220484,0.0006059084,0.00004898525,0.0004082858,0.01012102],"genre_scores_gemma":[0.06105218,0.03242725,0.0005387045,0.8597333,0.006032952,0.0004436162,0.00009475621,0.0005201817,0.03915703],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09962332,"threshold_uncertainty_score":0.999707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0914514605337021,"score_gpt":0.3391176875780616,"score_spread":0.2476662270443595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}