{"id":"W2589414013","doi":"10.1038/ncomms14570","title":"SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Key Research and Development Program of China; University of Toronto; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; National Natural Science Foundation of China","keywords":"Osteoclast; RANKL; Osteoblast; Phenotype; Cell biology; Regulator; Chemistry; Osteoporosis; Bone remodeling; Homeostasis; Downregulation and upregulation; Receptor; Internal medicine; Endocrinology; Cancer research; Biology; In vitro; Medicine; Biochemistry; Gene; Activator (genetics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228444,0.0001256653,0.0001292281,0.00004555835,0.0003697787,0.00009014949,0.0006680185,0.0002021902,0.000007933751],"category_scores_gemma":[0.000309113,0.000111612,0.00004632251,0.00006590733,0.0001609727,0.000023041,0.0003764264,0.0003257734,0.000006284301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001501349,"about_ca_system_score_gemma":0.00003572145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000104912,"about_ca_topic_score_gemma":0.001763816,"domain_scores_codex":[0.9992945,0.00008400216,0.000159101,0.0002222827,0.00008604283,0.0001540919],"domain_scores_gemma":[0.9976865,0.00003426936,0.0001726039,0.001955786,0.00008733643,0.00006348734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005807408,0.0009192788,0.09065016,0.00004938315,0.0001409868,0.000003686777,0.0003526066,0.00001787002,0.7969264,0.001040115,0.04780368,0.06151507],"study_design_scores_gemma":[0.002275037,0.0002058821,0.1991362,0.0002187098,0.00009527403,0.0000235471,0.0008646133,0.000119945,0.1971379,0.00007727518,0.5991111,0.0007345579],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806706,0.01480132,0.00002765349,0.002284895,0.0001149097,0.0001778488,0.0001241244,0.00001788475,0.001780819],"genre_scores_gemma":[0.9950417,0.001658345,0.001980223,0.0001546335,0.00005725354,0.00004382576,0.0007412963,0.00001939805,0.0003033422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5997885,"threshold_uncertainty_score":0.4551406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025964294319778,"score_gpt":0.2917030209295724,"score_spread":0.2814433779863746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}