{"id":"W2589414013","doi":"10.1038/ncomms14570","title":"SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Key Research and Development Program of China; University of Toronto; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; National Natural Science Foundation of China","keywords":"Osteoclast; RANKL; Osteoblast; Phenotype; Cell biology; Regulator; Chemistry; Osteoporosis; Bone remodeling; Homeostasis; Downregulation and upregulation; Receptor; Internal medicine; Endocrinology; Cancer research; Biology; In vitro; Medicine; Biochemistry; Gene; Activator (genetics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002476939,0.0006269173,0.0003002168,0.0004906207,0.0003185515,0.0003352491,0.0003457203,0.0004462741,0.001283367],"category_scores_gemma":[0.0001401541,0.0002791053,0.0003875875,0.0001599639,0.0002974943,0.0001826012,0.0003450806,0.0003704343,0.0004026618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003656113,"about_ca_system_score_gemma":0.0002713385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006604761,"about_ca_topic_score_gemma":0.001876616,"domain_scores_codex":[0.9997852,0.00004320155,0.00001505539,0.00003490463,0.00006505793,0.00005655302],"domain_scores_gemma":[0.9999002,0.0000115212,0.00004033901,0.00000958823,0.000008829663,0.00002957018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246448,0.00001806116,0.0003757155,0.00003422034,0.00000805639,0.0001244187,0.000009430575,0.00008806839,0.9975624,0.0001721679,0.0000669291,0.001415802],"study_design_scores_gemma":[0.00005465154,0.0001751882,0.00752028,0.000008824652,0.00002993978,0.0007751466,0.00004209252,0.001548821,0.9841484,0.00009312567,0.005594029,0.000009494723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870962,0.003957533,0.005301816,0.00022935,0.00005990215,0.00002988413,0.0003504108,0.0002060306,0.002768928],"genre_scores_gemma":[0.9936934,0.001139255,0.002716352,0.00006942337,0.00001810015,0.00002926204,0.0003092877,0.0000318793,0.001993052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001283367,"threshold_uncertainty_score":0.004293323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025964294319778,"score_gpt":0.2917030209295724,"score_spread":0.2814433779863746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}