{"id":"W2589460038","doi":"10.1152/ajpendo.00444.2016","title":"A model of chronic diabetic polyneuropathy: benefits from intranasal insulin are modified by sex and RAGE deletion","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital; Women and Children’s Health Research Institute; University of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Government of Canada; Juvenile Diabetes Research Foundation Canada; Canadian Diabetes Association","keywords":"Internal medicine; Medicine; Endocrinology; Nasal administration; Diabetes mellitus; Insulin; Rage (emotion); Advanced glycation end-product; Glycation; Immunology; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000407624,0.0009060368,0.0004536726,0.0007657519,0.0003428571,0.0003479585,0.0005219799,0.0005962177,0.002268668],"category_scores_gemma":[0.0001524087,0.0002997158,0.0004846555,0.0003502143,0.0005044552,0.0004439246,0.0003541462,0.001508891,0.0003430891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003375438,"about_ca_system_score_gemma":0.0003287911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006440373,"about_ca_topic_score_gemma":0.001385425,"domain_scores_codex":[0.9995335,0.00006389464,0.0000495724,0.0001427277,0.0001179873,0.00009229655],"domain_scores_gemma":[0.9994853,0.00004938429,0.000161605,0.00006766686,0.00003066276,0.0002054291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001906994,0.001248572,0.0008846118,0.00008735376,0.00001704517,0.0001872667,0.00007890582,0.0001350112,0.9924569,0.0001781391,0.00007940358,0.002739735],"study_design_scores_gemma":[0.0006586839,0.02845971,0.03329927,0.00006339067,0.0001658796,0.001690862,0.0002789681,0.002678429,0.9263787,0.0003719995,0.005901325,0.00005275774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954874,0.0005731319,0.001815642,0.0001157779,0.00008061316,0.0001174189,0.0006076972,0.00009011404,0.001112215],"genre_scores_gemma":[0.9728124,0.001374569,0.008843578,0.0002288337,0.00005622227,0.0005486342,0.00108946,0.00007480037,0.01497152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002268668,"threshold_uncertainty_score":0.007589459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430534031407766,"score_gpt":0.2665744938666519,"score_spread":0.2522691535525742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}