{"id":"W2589616108","doi":"10.1101/108761","title":"Genome-scale genetic interactions position the Mitotic Exit Network as a major antagonist of transient Topoisomerase II deficiency","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ministerio de Economía y Competitividad; Instituto de Salud Carlos III; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Forsknings- og Innovationsstyrelsen; European Commission; European Regional Development Fund; Danish Agency for Science and Higher Education; Agencia Canaria de Investigación, Innovación y Sociedad de la Información; Villum Fonden","keywords":"Anaphase; Mitosis; Biology; Downregulation and upregulation; Topoisomerase; Mitotic catastrophe; Mitotic exit; Cell biology; Gene; DNA; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008215872,0.0002400583,0.000230724,0.000135838,0.0001097829,0.0003788341,0.0001695624,0.0001913306,0.001449499],"category_scores_gemma":[0.00009019468,0.00009263447,0.0001880252,0.000113973,0.0002193511,0.0001294022,0.0002778711,0.0005236911,0.0002333845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038221,"about_ca_system_score_gemma":0.0001510368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006534733,"about_ca_topic_score_gemma":0.0009497884,"domain_scores_codex":[0.9999014,0.00001131779,0.000006284824,0.00003031762,0.00002701396,0.00002355534],"domain_scores_gemma":[0.9999084,0.00001533971,0.00002755116,0.00001257785,0.000008124565,0.00002802634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007679113,0.00001154155,0.0001583059,0.000009391698,0.000003053883,0.00001335073,0.000003122883,0.00005710487,0.999208,0.00006335357,0.00002423356,0.0003716027],"study_design_scores_gemma":[0.00001191852,0.0001724873,0.0135131,0.0000040911,0.00001890809,0.00007201196,0.00003391886,0.001491903,0.9831463,0.00007730192,0.001453868,0.000004190704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947708,0.0005538066,0.002667632,0.0001018792,0.00002982016,0.000009588331,0.000760611,0.0001155207,0.0009904441],"genre_scores_gemma":[0.9948738,0.0002497108,0.001345676,0.00005436951,0.000005312556,0.00001461868,0.000855467,0.00004346679,0.002557508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449499,"threshold_uncertainty_score":0.004849017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102575984347026,"score_gpt":0.2345504462891265,"score_spread":0.2242928478544239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}