{"id":"W2589754084","doi":"10.1016/j.yjmcc.2017.01.008","title":"Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta; University of Guelph","funders":"Heart and Stroke Foundation of Canada","keywords":"Circadian clock; Protein kinase B; Circadian rhythm; Internal medicine; Endocrinology; Biology; PTEN; Medicine; Signal transduction; Cell biology; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036558,0.0002264225,0.0005890846,0.0001172287,0.0006393259,0.0002170507,0.0006826795,0.0001210876,0.000006412068],"category_scores_gemma":[0.000999716,0.0001665935,0.0008193049,0.00007006563,0.0003280645,0.0001349314,0.0002383606,0.0004361579,0.00002319999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004678873,"about_ca_system_score_gemma":0.0001073696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104434,"about_ca_topic_score_gemma":0.000001073514,"domain_scores_codex":[0.9977522,0.0004688615,0.0004022703,0.0004170245,0.0005046873,0.000454957],"domain_scores_gemma":[0.9978183,0.00007647833,0.0002825856,0.001161048,0.00008000018,0.0005815975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002052511,0.00003639859,0.01052808,0.0000561754,0.0005383453,0.03947443,0.0008513587,0.006338369,0.9174789,0.01332089,0.0003124863,0.01085934],"study_design_scores_gemma":[0.003279882,0.0005064174,0.06832352,0.0001823539,0.001718608,0.00967266,0.000324893,0.0001666578,0.694839,0.001729045,0.2180889,0.001168096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820271,0.009825757,0.003995857,0.001432593,0.0009150322,0.0002401791,0.000008357373,0.00001183986,0.001543252],"genre_scores_gemma":[0.9981143,0.0002888497,0.00006188807,0.0006147,0.0006641382,0.000007329246,6.582843e-7,0.00003491348,0.0002131955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2226399,"threshold_uncertainty_score":0.6793485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179773451905721,"score_gpt":0.2451973895615416,"score_spread":0.2233996550424844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}