{"id":"W2589759270","doi":"10.1073/pnas.1700997114","title":"Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Université du Québec à Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Department of Defense","keywords":"Mitochondrion; Endocrinology; Internal medicine; Biology; Insulin resistance; Respiration; Skeletal muscle; Mitochondrial toxicity; Adipose tissue; Brown adipose tissue; Adenine nucleotide translocator; Type 2 diabetes; Insulin; Diabetes mellitus; Cell biology; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265055,0.0003861674,0.000219655,0.0002945679,0.000133768,0.000272132,0.0001303023,0.0002464257,0.0007570137],"category_scores_gemma":[0.00009454408,0.000166172,0.0001872553,0.0001673375,0.0001926053,0.00009704162,0.0002205023,0.0004691663,0.0002615387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002243481,"about_ca_system_score_gemma":0.00009096065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002911229,"about_ca_topic_score_gemma":0.0004413228,"domain_scores_codex":[0.999868,0.00002259411,0.00001500981,0.00003723775,0.0000365389,0.00002047748],"domain_scores_gemma":[0.9998639,0.00001505172,0.00005367561,0.00001286448,0.00001164055,0.00004286463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107145,0.00001210187,0.0004094981,0.00003455654,0.000008222541,0.0000737937,0.000006761756,0.00002966364,0.9984908,0.00003559386,0.00003255808,0.0007592455],"study_design_scores_gemma":[0.00005756514,0.0003904121,0.08024063,0.00003827204,0.00006987798,0.001793294,0.0000982876,0.001323547,0.9104069,0.0002452116,0.005323017,0.00001303674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935247,0.002752592,0.001952012,0.0001490486,0.00003171191,0.00001628682,0.0004341492,0.00007891526,0.001060597],"genre_scores_gemma":[0.9945794,0.001899915,0.001009137,0.00007663256,0.000009953549,0.00002519912,0.0006254689,0.00001823635,0.001756018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007570137,"threshold_uncertainty_score":0.002532423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02826616477534665,"score_gpt":0.3081572240374311,"score_spread":0.2798910592620845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}