{"id":"W2589782040","doi":"10.1096/fj.201601188r","title":"Heat shock protein 27–derived atheroprotection involves reverse cholesterol transport that is dependent on GM‐CSF to maintain ABCA1 and ABCG1 expression in ApoE <sup>−</sup> / <sup>−</sup> mice.","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Heart Research Institute; University of Calgary; Heart and Stroke Foundation of Canada","keywords":"ABCG1; ABCA1; Downregulation and upregulation; Reverse cholesterol transport; Heat shock protein; Cholesterol; Apolipoprotein E; Cytokine; Foam cell; Chemistry; Granulocyte macrophage colony-stimulating factor; Monocyte; Endocrinology; Biology; Cell biology; Immunology; Internal medicine; Transporter; Lipoprotein; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276753,0.0005702741,0.0002799797,0.0004247498,0.0001679885,0.0002625423,0.0001893448,0.0002961513,0.001982263],"category_scores_gemma":[0.0001180636,0.000235608,0.0004674435,0.0001470546,0.0005665798,0.0002021215,0.0002282865,0.001120207,0.000470535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003132011,"about_ca_system_score_gemma":0.0002542429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004220359,"about_ca_topic_score_gemma":0.0005310818,"domain_scores_codex":[0.9998491,0.00003542884,0.00001687774,0.00002384408,0.00003673737,0.00003804271],"domain_scores_gemma":[0.9997489,0.00001817752,0.0001028314,0.00003979601,0.00002090158,0.0000694027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003924076,0.00005692952,0.0001486734,0.00003049456,0.000006177004,0.0000594012,0.000009890168,0.00003639245,0.9983852,0.0001329195,0.00004548896,0.000696084],"study_design_scores_gemma":[0.00006723213,0.0006797399,0.006361772,0.00001220626,0.00002408473,0.0003870119,0.00002796237,0.0007596362,0.9895509,0.00008894849,0.002033625,0.000006973266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935964,0.0009710731,0.00343363,0.0003108344,0.00005188662,0.0000564968,0.0006092241,0.0001359827,0.0008345089],"genre_scores_gemma":[0.9919321,0.0007604296,0.002842358,0.0001307984,0.00002249942,0.00008929077,0.0008221005,0.00004455638,0.003355922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001982263,"threshold_uncertainty_score":0.006631374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215435196841972,"score_gpt":0.2506359491326673,"score_spread":0.2284815971642476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}