{"id":"W2589782040","doi":"10.1096/fj.201601188r","title":"Heat shock protein 27–derived atheroprotection involves reverse cholesterol transport that is dependent on GM‐CSF to maintain ABCA1 and ABCG1 expression in ApoE <sup>−</sup> / <sup>−</sup> mice.","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Heart Research Institute; University of Calgary; Heart and Stroke Foundation of Canada","keywords":"ABCG1; ABCA1; Downregulation and upregulation; Reverse cholesterol transport; Heat shock protein; Cholesterol; Apolipoprotein E; Cytokine; Foam cell; Chemistry; Granulocyte macrophage colony-stimulating factor; Monocyte; Endocrinology; Biology; Cell biology; Immunology; Internal medicine; Transporter; Lipoprotein; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00138087,0.0005211286,0.0006643768,0.0003106653,0.0009518982,0.0002057663,0.0005311731,0.0003033956,0.0003322299],"category_scores_gemma":[0.0000419064,0.0003461226,0.0002554196,0.0001231062,0.000177469,0.0004470624,0.00005661324,0.001320125,0.00004498674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496108,"about_ca_system_score_gemma":0.0001280235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002535122,"about_ca_topic_score_gemma":0.0002528738,"domain_scores_codex":[0.9968643,0.0001913282,0.0006493637,0.000617385,0.0009520577,0.0007255352],"domain_scores_gemma":[0.9982302,0.00002709378,0.000215865,0.0008902567,0.0001063705,0.0005302408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005224949,0.0004992929,0.01125191,0.0002797414,0.0001557825,0.0009514881,0.01570499,0.001702044,0.9582796,0.00003099216,0.0003067213,0.005612468],"study_design_scores_gemma":[0.01025217,0.001372034,0.03259546,0.005855206,0.0003229469,0.0007454987,0.01273551,0.001256875,0.9311059,0.0008678947,0.002093851,0.0007966867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895756,0.0001999762,0.00270031,0.004891921,0.0001936363,0.002046743,0.00003708668,0.00005460699,0.0003001218],"genre_scores_gemma":[0.994647,0.0003358968,0.0009103716,0.00116721,0.0004265193,0.00009830119,0.00001509961,0.00008637294,0.002313203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02717374,"threshold_uncertainty_score":0.9998991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215435196841972,"score_gpt":0.2506359491326673,"score_spread":0.2284815971642476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}