{"id":"W2589784053","doi":"10.1200/jco.2005.23.16_suppl.7007","title":"Molecular analysis of the epidermal growth factor receptor (EGFR) gene and protein expression in patients treated with erlotinib in National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial BR.21","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Erlotinib; Medicine; Immunohistochemistry; Epidermal growth factor receptor; Gefitinib; Erlotinib Hydrochloride; KRAS; Internal medicine; Cancer; Oncology; Polysomy; Copy-number variation; Exon; Fluorescence in situ hybridization; EGFR inhibitors; Chromogenic in situ hybridization; Cancer research; Pathology; Gene expression; In situ hybridization; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002109074,0.0007111724,0.001644678,0.0003276861,0.0003741914,0.0008052364,0.0004853806,0.0009698273,0.002629627],"category_scores_gemma":[0.001385572,0.0002799362,0.0009886764,0.0003885659,0.0004691462,0.0003743407,0.000185519,0.001681284,0.0003976122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009914837,"about_ca_system_score_gemma":0.0008491352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002222608,"about_ca_topic_score_gemma":0.006830398,"domain_scores_codex":[0.9991885,0.0004783656,0.00004804831,0.0001052368,0.00007822602,0.0001016211],"domain_scores_gemma":[0.9993712,0.0001339032,0.000196677,0.00004384337,0.00005431206,0.0002000036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.921162,0.003137381,0.02148169,0.0007261939,0.001769659,0.0001122161,0.00007628024,0.0008882807,0.009709527,0.0002125293,0.004028101,0.03669621],"study_design_scores_gemma":[0.7268875,0.1295546,0.1310784,0.0001624102,0.003223363,0.0003983103,0.00004669325,0.001419192,0.002203692,0.0003828429,0.004582409,0.00006053941],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896235,0.005996853,0.0001103127,0.000555401,0.00009705803,0.0005696709,0.001018374,0.00002426823,0.002004539],"genre_scores_gemma":[0.99403,0.001722997,0.0002739029,0.0005577903,0.0001477388,0.0004947761,0.00177056,0.000007560619,0.0009946879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002629627,"threshold_uncertainty_score":0.011154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09834642691559599,"score_gpt":0.4801009994690773,"score_spread":0.3817545725534813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}