{"id":"W2589792316","doi":"10.1182/blood.v118.21.3303.3303","title":"Eculizumab Is An Effective Long-Term Treatment In Patients with Atypical Hemolytic Uremic Syndrome (aHUS) Previously Receiving Chronic Plasma Exchange/Infusion (PE/PI): Extension Study Results,","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Eculizumab; Atypical hemolytic uremic syndrome; Thrombotic microangiopathy; Dialysis; Clinical endpoint; Internal medicine; Surrogate endpoint; Regimen; Renal function; Gastroenterology; Surgery; Randomized controlled trial; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001075854,0.000559216,0.0009983939,0.0002120944,0.0002213368,0.0005428036,0.0003610661,0.0005943595,0.002777029],"category_scores_gemma":[0.000783266,0.0002495059,0.000796437,0.0001993102,0.0003979575,0.0006327083,0.0002579545,0.001498034,0.0003129504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000350591,"about_ca_system_score_gemma":0.0005160627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004610614,"about_ca_topic_score_gemma":0.001140909,"domain_scores_codex":[0.999737,0.0001361514,0.00002185725,0.00003780194,0.00002193234,0.00004535493],"domain_scores_gemma":[0.9994524,0.0001297522,0.0001324338,0.00003685562,0.00002795938,0.0002204587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8221847,0.02986474,0.01243979,0.0009533329,0.001454713,0.0002124025,0.0001708023,0.0006226707,0.01699204,0.0001077592,0.001272608,0.1137245],"study_design_scores_gemma":[0.5580426,0.4041267,0.03277608,0.00008340779,0.000954679,0.0002417071,0.00004598473,0.0007102513,0.001614419,0.00007587821,0.00130978,0.00001844185],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959401,0.002733635,0.0001429801,0.0001481686,0.0000309062,0.0002548359,0.0002062193,0.00001647705,0.0005267625],"genre_scores_gemma":[0.9972046,0.001100187,0.0003306884,0.000179461,0.00007995847,0.0002779957,0.0003414277,0.000003210868,0.0004824452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002777029,"threshold_uncertainty_score":0.009290099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860261064052004,"score_gpt":0.242432139954303,"score_spread":0.223829529313783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}