{"id":"W2589885101","doi":"10.1182/blood.v128.22.358.358","title":"IKZF1 Regulates BRD4 Retention and Recruitement at Enhancer in Myeloma Cells: Role of BRD4 in IMiDs Resistance","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Enhancer; BRD4; Biology; Bromodomain; Cell culture; Transcription factor; Enhancer RNAs; RNA polymerase II; Molecular biology; Chromatin; Cancer research; Gene expression; Gene; Promoter; Histone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275654,0.0002540694,0.0002628401,0.0002453016,0.0002253046,0.0004339427,0.0002428621,0.0003048681,0.003476657],"category_scores_gemma":[0.0001081855,0.0001559214,0.000349375,0.0001873273,0.0002209246,0.0001998128,0.0003412656,0.000615118,0.001254429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005951892,"about_ca_system_score_gemma":0.0002074768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150929,"about_ca_topic_score_gemma":0.001237298,"domain_scores_codex":[0.9998272,0.00001392362,0.00001263487,0.00005233952,0.00004108779,0.00005282816],"domain_scores_gemma":[0.9998983,0.000007589719,0.00003665099,0.00001233205,0.00001603364,0.0000291209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001323662,0.00001449277,0.0007830902,0.00003623929,0.000003845984,0.00002995203,0.00001111124,0.00005330998,0.9979442,0.00005094559,0.00009201156,0.000848512],"study_design_scores_gemma":[0.00002054012,0.0001367213,0.03529424,0.0000107181,0.00002248745,0.0002337356,0.00008294961,0.001188439,0.9587115,0.00006876817,0.004222677,0.000007132188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876271,0.00309554,0.003021406,0.0002139288,0.00004626937,0.00002789212,0.003213354,0.000256896,0.002497587],"genre_scores_gemma":[0.9931289,0.0004758234,0.0008317597,0.00006846398,0.000006624814,0.00001886374,0.001888923,0.00003354872,0.003547073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003476657,"threshold_uncertainty_score":0.01163054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005765579804463464,"score_gpt":0.2064685661456074,"score_spread":0.200702986341144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}