{"id":"W2589931616","doi":"10.1080/23723556.2017.1297101","title":"Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis","year":2017,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Interactome; Receptor tyrosine kinase; Protein tyrosine phosphatase; Phosphatase; Biology; Signal transduction; Computational biology; Receptor Protein-Tyrosine Kinases; Cell biology; Kinase; PTPN11; Phosphorylation; Biochemistry; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004767125,0.0003374353,0.0006476588,0.000226665,0.0001879519,0.00005367295,0.0007261244,0.0003359553,0.0001644134],"category_scores_gemma":[0.001043373,0.0003631038,0.0003295582,0.0003140501,0.0003118229,0.00002126085,0.000424523,0.0002381003,0.00002391138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008884326,"about_ca_system_score_gemma":0.0001583349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007687329,"about_ca_topic_score_gemma":0.0002436904,"domain_scores_codex":[0.9976104,0.0002789567,0.0006584011,0.000750513,0.0002254969,0.0004762158],"domain_scores_gemma":[0.9975867,0.00004079274,0.0006464323,0.001390369,0.0001801332,0.0001556004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004893628,0.0004543777,0.008691643,0.00004129785,0.0003812285,0.00009089602,0.00001818498,0.0002152954,0.9865245,0.00007554458,0.0009895165,0.00202816],"study_design_scores_gemma":[0.001648935,0.0007377788,0.0006904797,0.00004787267,0.0002272948,0.000003394419,0.0000352399,0.0001288173,0.9687827,0.00002979725,0.02732581,0.0003419148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659486,0.01613862,0.01581292,0.0003119259,0.0001597231,0.0008017011,0.0006626824,0.00001959617,0.0001442226],"genre_scores_gemma":[0.9916646,0.00008178637,0.0043631,0.0001345874,0.00006389307,0.0002308822,0.003011078,0.00004931927,0.0004007364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02633629,"threshold_uncertainty_score":0.9998821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006615416363258,"score_gpt":0.2670783677547796,"score_spread":0.257012213591147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}