{"id":"W2589966558","doi":"10.1111/febs.14049","title":"Monomer‐to‐dimer transition of <i>Brucella suis</i> type <scp>IV</scp> secretion system component VirB8 induces conformational changes","year":2017,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Montréal; Canada Foundation for Innovation; Fonds de Recherche du Québec-Société et Culture; Bristol-Myers Squibb Foundation","keywords":"Dimer; Secretion; Chemistry; Periplasmic space; Conformational change; Biophysics; Heteronuclear single quantum coherence spectroscopy; Monomer; Stereochemistry; Biochemistry; Biology; Nuclear magnetic resonance spectroscopy; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009162995,0.0001931008,0.0001593278,0.00008834571,0.0001010901,0.0001340869,0.0001522262,0.0001726822,0.0009203509],"category_scores_gemma":[0.0001368154,0.00009716838,0.0001531236,0.00009605542,0.0001116544,0.00008882578,0.0001098467,0.0003250848,0.0001772653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186019,"about_ca_system_score_gemma":0.0001117928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004280121,"about_ca_topic_score_gemma":0.0005766057,"domain_scores_codex":[0.9999059,0.00001991483,0.000005614944,0.00001740661,0.00003160936,0.00001950926],"domain_scores_gemma":[0.9999262,0.00001554047,0.00001785902,0.000007576103,0.00001079692,0.00002190396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002982561,0.00001329619,0.0001341488,0.000009281397,0.000002175926,0.00001595926,0.000006168126,0.00002098392,0.9994501,0.0000123053,0.00002347382,0.0002822644],"study_design_scores_gemma":[0.00001671585,0.0003006548,0.007746078,0.000004043604,0.000007854101,0.0001504723,0.00002382872,0.0006584655,0.9901912,0.00002592028,0.000870186,0.000004485471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983272,0.0003765626,0.0005290592,0.00006661082,0.000008263357,0.000008767704,0.00009295284,0.00002106043,0.0005696148],"genre_scores_gemma":[0.99823,0.0001681475,0.0006226636,0.00006812109,0.000003768124,0.00001155566,0.0002866993,0.000007501446,0.0006014413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009203509,"threshold_uncertainty_score":0.003078878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0919737665167808,"score_gpt":0.3322419290119995,"score_spread":0.2402681624952187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}