{"id":"W2590011141","doi":"10.1182/blood.v108.11.5118.5118","title":"Safety and Efficacy of Bortezomib (VELCADE™) in 104 Patients with Relapsed and/or Refractory Multiple Myeloma Who Have Received at Least Two Previous Lines of Therapy: Impact of Cytogenetics on Response from a Canadian Cohort.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bortezomib; Medicine; Multiple myeloma; Internal medicine; Refractory (planetary science); Proteasome inhibitor; Neutropenia; Gastroenterology; Progressive disease; Dexamethasone; Surgery; Oncology; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005080914,0.0005371993,0.0007907557,0.0003421378,0.00104269,0.0005387939,0.0005473361,0.00047378,0.001298986],"category_scores_gemma":[0.0006681985,0.0003448468,0.0007550331,0.00081271,0.0007512194,0.000240639,0.0003285646,0.000670194,0.0002977713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006199338,"about_ca_system_score_gemma":0.003508173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.338157,"about_ca_topic_score_gemma":0.4083093,"domain_scores_codex":[0.9997025,0.00004532561,0.00001733026,0.00006175691,0.00009012585,0.0000830253],"domain_scores_gemma":[0.9994832,0.00005788824,0.0001132187,0.00002534639,0.0001116777,0.0002086531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07666463,0.004836953,0.8455647,0.0003220446,0.0008605015,0.0009184996,0.001070108,0.001991153,0.02186023,0.0000813373,0.002328025,0.04350181],"study_design_scores_gemma":[0.006202394,0.01788659,0.9700734,0.00002128117,0.0004105937,0.0005837591,0.0002184966,0.0009159775,0.001447262,0.00002765716,0.002170641,0.00004202987],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986435,0.0003592208,0.00003676197,0.00005492975,0.000005535421,0.0000766977,0.0004559295,0.000005917992,0.0003615627],"genre_scores_gemma":[0.9975634,0.0003187009,0.0001330566,0.0001026308,0.00001727567,0.00004616327,0.001362013,0.000003457622,0.0004534802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.338157,"threshold_uncertainty_score":0.6723773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397603992933391,"score_gpt":0.2763486512842656,"score_spread":0.2623726113549316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}