{"id":"W2590054370","doi":"10.1016/j.bbi.2017.02.018","title":"Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models","year":2017,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Electron Spin Resonance Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Multiple Sclerosis Society of Canada","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Medicine; FOXP3; Pharmacology; Immunology; T cell; Reactive oxygen species; Immune system; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003610243,0.0006640238,0.0008693339,0.0006400452,0.0002854744,0.0003585351,0.0003824532,0.0006658276,0.001018456],"category_scores_gemma":[0.0001608273,0.000225538,0.0004941594,0.0003822234,0.000415738,0.0004632277,0.0002661148,0.001449549,0.0002666921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202767,"about_ca_system_score_gemma":0.0003844269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000399945,"about_ca_topic_score_gemma":0.0006721388,"domain_scores_codex":[0.99977,0.00003337854,0.00002375839,0.0000505535,0.00006759525,0.00005477785],"domain_scores_gemma":[0.9998416,0.00001176535,0.00005477843,0.00001875292,0.0000217349,0.0000513431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074461,0.0008228055,0.0001308316,0.0001850297,0.00002332258,0.00006611674,0.00003415669,0.00008410839,0.992017,0.00008369448,0.0001083813,0.005370037],"study_design_scores_gemma":[0.0004596906,0.01999342,0.004768054,0.00005143479,0.0001679428,0.0003790284,0.00003468943,0.0007996667,0.967114,0.0001558563,0.006049987,0.00002617324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859545,0.007288875,0.003989315,0.0003073566,0.0001540178,0.0001502959,0.000372755,0.0002477531,0.001535271],"genre_scores_gemma":[0.9810641,0.007263904,0.006369127,0.0001617242,0.0001305422,0.0003660864,0.0008066237,0.00003923598,0.00379875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018456,"threshold_uncertainty_score":0.003407121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07161641050153927,"score_gpt":0.277598659490874,"score_spread":0.2059822489893348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}