{"id":"W2590057071","doi":"10.1200/jco.2016.34.4_suppl.64","title":"Evaluation of circulating VEGF based biomarkers in INTEGRATE: A randomized phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC)—A study by the Australasian Gastrointestinal Trials Group (AGITG).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; McGill University Health Centre","funders":"","keywords":"Medicine; Internal medicine; VEGF receptors; Ramucirumab; Interleukin 8; Oncology; Bevacizumab; Gastroenterology; Placebo; Vascular endothelial growth factor; Refractory (planetary science); Proportional hazards model; Biomarker; Cancer; Pathology; Cytokine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.08004111,0.0002972807,0.005453927,0.0008502256,0.00004208949,0.000009338202,0.0003233169,0.0001588358,0.0002460792],"category_scores_gemma":[0.03443831,0.000148271,0.0008271176,0.0007454128,0.0002669395,0.0001911588,0.00006396696,0.0007819053,4.456235e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007083091,"about_ca_system_score_gemma":0.001950854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004469761,"about_ca_topic_score_gemma":0.001284792,"domain_scores_codex":[0.9791261,0.009952174,0.008583643,0.0003980416,0.00157459,0.0003654266],"domain_scores_gemma":[0.975139,0.01490695,0.008391195,0.0003402817,0.001046044,0.0001765617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7621843,0.01509332,0.08217025,0.00002217694,0.001454179,0.0001191947,0.0003621545,0.0003405321,0.001013429,0.000001553609,0.0001381043,0.1371008],"study_design_scores_gemma":[0.9191166,0.03300324,0.03726741,0.0005575601,0.004397468,0.00001955037,0.003893685,0.00155882,0.00003005094,0.00003120906,0.00002748663,0.00009689223],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889242,0.0004104811,0.0002688011,0.002084398,0.0005936393,0.007568651,0.000004670992,0.000006181118,0.0001389466],"genre_scores_gemma":[0.9989251,0.0000664779,0.0003889507,0.00006729643,0.0002278602,0.0002524653,0.00000225787,0.00002028489,0.00004932924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1569323,"threshold_uncertainty_score":0.973695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2280426544723023,"score_gpt":0.5213034478385022,"score_spread":0.2932607933661999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}