{"id":"W2590057071","doi":"10.1200/jco.2016.34.4_suppl.64","title":"Evaluation of circulating VEGF based biomarkers in INTEGRATE: A randomized phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC)—A study by the Australasian Gastrointestinal Trials Group (AGITG).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; McGill University Health Centre","funders":"","keywords":"Medicine; Internal medicine; VEGF receptors; Ramucirumab; Interleukin 8; Oncology; Bevacizumab; Gastroenterology; Placebo; Vascular endothelial growth factor; Refractory (planetary science); Proportional hazards model; Biomarker; Cancer; Pathology; Cytokine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002205347,0.00144338,0.003308595,0.0005166772,0.0003369698,0.00100311,0.000846319,0.00180637,0.003151703],"category_scores_gemma":[0.001604966,0.0006599585,0.001812809,0.0005066359,0.001029001,0.0008441347,0.0004158772,0.002288333,0.0005557145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005946661,"about_ca_system_score_gemma":0.0009023013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005749051,"about_ca_topic_score_gemma":0.00172259,"domain_scores_codex":[0.9993528,0.000363308,0.00003845821,0.00009674075,0.00006812406,0.00008060561],"domain_scores_gemma":[0.9990841,0.0001967167,0.0002883329,0.00008122564,0.000065732,0.0002838671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.966501,0.008824891,0.001549272,0.0006542631,0.001274024,0.00003315023,0.00004689963,0.0002618414,0.004568983,0.00005037876,0.000345406,0.01588983],"study_design_scores_gemma":[0.9040742,0.09062525,0.003610658,0.00002342619,0.0005308235,0.00002948374,0.00001502082,0.0001904261,0.0004364655,0.00003613902,0.0004176544,0.00001049989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893631,0.005450435,0.0004206648,0.0003259322,0.0001797711,0.002597765,0.000685346,0.00009317607,0.0008837901],"genre_scores_gemma":[0.9891195,0.002709586,0.001319925,0.0007662692,0.0003416009,0.003433429,0.001033264,0.00001972019,0.001256693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003308595,"threshold_uncertainty_score":0.01166308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2280426544723023,"score_gpt":0.5213034478385022,"score_spread":0.2932607933661999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}