{"id":"W2590085384","doi":"10.1200/jco.2013.31.4_suppl.450","title":"A multicenter phase I study of intravenous administration of reolysin in combination with irinotecan/fluorouracil/leucovorin (FOLFIRI) in patients (pts) with oxaliplatin-refractory/intolerant <i>KRAS-</i>mutant metastatic colorectal cancer (mCRC).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Neutropenia; FOLFIRI; Internal medicine; Irinotecan; Gastroenterology; KRAS; Febrile neutropenia; Phases of clinical research; Colorectal cancer; Leukopenia; Toxicity; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007608178,0.0001698718,0.0008747034,0.0001550328,0.00001892213,0.00000993134,0.0001683851,0.000135031,0.00004063008],"category_scores_gemma":[0.0003482457,0.0001151213,0.00009487404,0.0001912898,0.0001510391,0.00003489208,0.00004083926,0.0003753038,8.87459e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607908,"about_ca_system_score_gemma":0.001037261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001781436,"about_ca_topic_score_gemma":0.01424241,"domain_scores_codex":[0.9968525,0.0005362902,0.00169268,0.0002467623,0.0004365221,0.0002351986],"domain_scores_gemma":[0.9972164,0.00022175,0.001611461,0.0001578633,0.0006397089,0.0001528072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07764939,0.08495816,0.6509717,0.00007468226,0.001138045,0.0003246129,0.0009410708,0.0003636396,0.02508235,0.000003474654,0.00004325017,0.1584496],"study_design_scores_gemma":[0.07407437,0.2541,0.6517668,0.0001514748,0.0001925818,0.00002498941,0.0006871007,0.0001868727,0.01846039,0.00001750603,0.0001660137,0.000171861],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986743,0.00008196977,0.00005210695,0.0001212536,0.0000959027,0.0009147848,0.00001892734,0.000001179136,0.00003951729],"genre_scores_gemma":[0.9992874,0.0001185641,0.000411172,0.00003595085,0.00004314635,0.0000607198,0.00002041184,0.00001489563,0.000007776186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1691418,"threshold_uncertainty_score":0.7947599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04136524051435573,"score_gpt":0.4128143350015649,"score_spread":0.3714490944872092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}