{"id":"W2590085384","doi":"10.1200/jco.2013.31.4_suppl.450","title":"A multicenter phase I study of intravenous administration of reolysin in combination with irinotecan/fluorouracil/leucovorin (FOLFIRI) in patients (pts) with oxaliplatin-refractory/intolerant <i>KRAS-</i>mutant metastatic colorectal cancer (mCRC).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Neutropenia; FOLFIRI; Internal medicine; Irinotecan; Gastroenterology; KRAS; Febrile neutropenia; Phases of clinical research; Colorectal cancer; Leukopenia; Toxicity; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001287926,0.001380405,0.001416682,0.0003887811,0.0004421555,0.0009837389,0.0009053063,0.001056715,0.002239973],"category_scores_gemma":[0.0008020683,0.0006739156,0.0008566697,0.0004083394,0.001045815,0.0008491857,0.0002569383,0.002337531,0.0006200103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001073951,"about_ca_system_score_gemma":0.001858172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258202,"about_ca_topic_score_gemma":0.002638014,"domain_scores_codex":[0.9995418,0.0002346374,0.00001877535,0.0000813521,0.00003072972,0.00009274271],"domain_scores_gemma":[0.9993244,0.00008850137,0.0001621029,0.00006632259,0.00003852393,0.0003201365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.678114,0.1343342,0.007156462,0.0005403557,0.0009152647,0.0003788405,0.00052533,0.003762014,0.1014892,0.0003455438,0.002753304,0.06968551],"study_design_scores_gemma":[0.2418503,0.7403418,0.007885922,0.00002260127,0.000290717,0.0002623943,0.00006813871,0.001041881,0.00653178,0.0001076878,0.001572708,0.00002409036],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945635,0.000611839,0.0007347406,0.0002401305,0.0000644678,0.002256697,0.0004499849,0.00009289527,0.0009857109],"genre_scores_gemma":[0.9938426,0.0005721748,0.001593272,0.0002723987,0.00008178884,0.001477048,0.00084582,0.00002332389,0.001291632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002239973,"threshold_uncertainty_score":0.007792115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04136524051435573,"score_gpt":0.4128143350015649,"score_spread":0.3714490944872092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}